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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD163 Antibody Picoband®

SKU : BHA21007130

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Mfr.No.	PA1874, PA1874-10ug, PA1874-Biotin, PA1874-Cy3, PA1874-Dylight488, PA1874-Dylight550, PA1874-Dylight594, PA1874-FITC, PA1874-HRP, PA1874-APC, PA1874-PE, PA1874-iFluor647, PA1874-carrier-free
Alternative Names	Scavenger receptor cysteine-rich type 1 protein M130
Background	CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alteatively spliced transcript variants encoding different isoforms have been described for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD163 Antibody catalog # PA1874. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, vi
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human CD163.
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Scavenger receptor cysteine-rich type 1 protein M130;Hemoglobin scavenger receptor;CD163;Soluble CD163;sCD163;CD163;M130;
Tissue Specificity	Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q86VB7
Gene Name	CD163
Sequence	Contains 9 SRCR domains.
Subcellular Location	Soluble CD163: Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Fabriek, B. O., van Bruggen, R., Deng, D. M., Ligtenberg, A. J. M., Nazmi, K., Schoagel, K., Vloet, R. P. M., Dijkstra, C. D., van den Berg, T. K. The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria. Blood 113: 887-892, 2009. <br /><br />2. Ritter, M., Buechler, C., Langmann, T., Schmitz, G.Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily. Biochem. Biophys. Res. Commun. 260: 466-474, 1999. <br /><br />3. Stover, C. M., Schleypen, J., Gronlund, J., Speicher, M. R., Schwaeble, W. J., Holmskov, U. Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis. Cytogenet. Cell Genet. 90: 246-247, 2000.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007130-1	PA1874	-	100 ug	$370		Add to Cart
BHA21007130-2	PA1874-10ug	Sample	10 ug	$99		Add to Cart
BHA21007130-3	PA1874-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007130-4	PA1874-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007130-5	PA1874-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007130-6	PA1874-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007130-7	PA1874-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007130-8	PA1874-FITC	FITC	100 ug	$570		Add to Cart
BHA21007130-9	PA1874-HRP	HRP	100 ug	$570		Add to Cart
BHA21007130-10	PA1874-APC	APC	100 ug	$670		Add to Cart
BHA21007130-11	PA1874-PE	PE	100 ug	$670		Add to Cart
BHA21007130-12	PA1874-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007130-13	PA1874-carrier-free	carrier-free	100 ug	$370		Add to Cart

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