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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD16/Fcgr3 Antibody Picoband®

SKU : BHA21003677

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Mfr.No.	A32617, A32617-10ug, A32617-Biotin, A32617-Cy3, A32617-Dylight488, A32617-Dylight550, A32617-Dylight594, A32617-FITC, A32617-HRP, A32617-APC, A32617-PE, A32617-iFluor647, A32617-carrier-free
Alternative Names	retrotransposon Gag like 10
Background	Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcgammaR). FcgammaR is divided into three classes, Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcgammaRIIIa and CD16b/FcgammaRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CD16/Fcgr3 Antibody Picoband® catalog # A32617. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Could induce apoptosis in a BH3 domain-dependent manner. The interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.
Host	Rabbit
Immunogen Region	E.coli-derived mouse CD16/Fcgr3 recombinant protein (Position: A31-T215).
Isotype	Rabbit IgG
Molecular Weight	30 kDa
Reactivity	Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Protein Bop; BH3-only protein; Retrotransposon Gag-like protein 10; RTL10; BOP, C22orf29
Tissue Specificity	Ubiquitously expressed.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P08508
Gene Id	14131
Gene Name	Fcgr3
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Mouse ELISA, 0.1-0.5 ug/ml, -

Reference	1. Pinheiro da Silva, F., Aloulou, M., Skuik, D., Benhamou, M., Andremont, A., Velasco, I. T., Chiamolera, M., Verbeek, J. S., Launay, P., Monteiro, R. C. CD16 promotes Escherichia coli sepsis through an FcR-gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation. Nature Med. 13: 1368-1374, 2007. 2. Robinson, J. I., Carr, I. M., Cooper, D. L., Rashid, L. H., Martin, S. G., Emery, P., Isaacs, J. D., Barton, A., BRAGGSS, Wilson, A. G., Barrett, J. H., Morgan, A. W. Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis. Hum. Mutat. 33: 741-749, 2012.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003677-1	A32617	-	100 ug	$370		Add to Cart
BHA21003677-2	A32617-10ug	Sample	10 ug	$99		Add to Cart
BHA21003677-3	A32617-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003677-4	A32617-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003677-5	A32617-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003677-6	A32617-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003677-7	A32617-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003677-8	A32617-FITC	FITC	100 ug	$570		Add to Cart
BHA21003677-9	A32617-HRP	HRP	100 ug	$570		Add to Cart
BHA21003677-10	A32617-APC	APC	100 ug	$670		Add to Cart
BHA21003677-11	A32617-PE	PE	100 ug	$670		Add to Cart
BHA21003677-12	A32617-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003677-13	A32617-carrier-free	carrier-free	100 ug	$370		Add to Cart

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