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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD135/FLT3 Antibody Picoband®

SKU : BHA21004388

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Mfr.No.	A00188-5, A00188-5-10ug, A00188-5-Biotin, A00188-5-Cy3, A00188-5-Dylight488, A00188-5-Dylight550, A00188-5-Dylight594, A00188-5-FITC, A00188-5-HRP, A00188-5-APC, A00188-5-PE, A00188-5-iFluor647, A00188-5-carrier-free
Alternative Names	FMS-like tyrosine kinase 3
Background	Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CD135/FLT3 Antibody Picoband® catalog # A00188-5. Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activatio
Host	Rabbit
Immunogen Region	E.coli-derived human CD135/FLT3 recombinant protein (Position: A66-S993).
Isotype	Rabbit IgG
Molecular Weight	160 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Receptor-type tyrosine-protein kinase FLT3; 2.7.10.1; FL cytokine receptor; Fetal liver kinase 2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Tyrosine-protein kinase receptor flk-2; CD135; Flt3; Flk-2, Flt-3;
Tissue Specificity	Hematopoietic stem and progenitor cell- enriched populations. Found in brain, placenta and testis.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P36888
Gene Id	2322
Gene Name	FLT3
Subcellular Location	Membrane; Constitutively activated mutant forms with inteal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Abu-Duhier, F. M., Goodeve, A. C., Wilson, G. A., Care, R. S., Peake, I. R., Reilly, J. T. Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. Brit. J. Haemat. 113: 983-988, 2001. <br /><br />2. Abu-Duhier, F. M., Goodeve, A. C., Wilson, G. A., Gari, M. A., Peake, I. R., Rees, D. C., Vanderberghe, E. A., Winship, P. R., Reilly, J. T. FLT3 inteal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group. Brit. J. Haemat. 111: 190-195, 2000.<br /><br />3. Ansari-Lari, M. A., Yang, C.-F., Tinawi-Aljundi, R., Cooper, L., Long, P., Allan, R. H., Borowitz, M. J., Berg, K. D., Murphy, K. M. FLT3 mutations in myeloid sarcoma. Brit. J. Haemat. 126: 785-791, 2004.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004388-1	A00188-5	-	100 ug	$370		Add to Cart
BHA21004388-2	A00188-5-10ug	Sample	10 ug	$99		Add to Cart
BHA21004388-3	A00188-5-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004388-4	A00188-5-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004388-5	A00188-5-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004388-6	A00188-5-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004388-7	A00188-5-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004388-8	A00188-5-FITC	FITC	100 ug	$570		Add to Cart
BHA21004388-9	A00188-5-HRP	HRP	100 ug	$570		Add to Cart
BHA21004388-10	A00188-5-APC	APC	100 ug	$670		Add to Cart
BHA21004388-11	A00188-5-PE	PE	100 ug	$670		Add to Cart
BHA21004388-12	A00188-5-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004388-13	A00188-5-carrier-free	carrier-free	100 ug	$370		Add to Cart

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