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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CBL Antibody Picoband®

SKU : BHA21007069

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Mfr.No.	PA1800, PA1800-10ug, PA1800-Biotin, PA1800-Cy3, PA1800-Dylight488, PA1800-Dylight550, PA1800-Dylight594, PA1800-FITC, PA1800-HRP, PA1800-APC, PA1800-PE, PA1800-iFluor647, PA1800-carrier-free
Alternative Names	E3 ubiquitin-protein ligase CBL
Background	CBL (Cbl proto-oncogene) is also known as C-CBL, RNF55, CBL2 and E3 ubiquitin protein ligase. Wei et al. (1990) mapped the CBL gene to chromosome 11q23.3-qter by molecular characterization of the breakpoints in 2 somatic cell hybrids. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CBL Antibody catalog # PA1800. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, a
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human CBL, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	120 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	E3 ubiquitin-protein ligase CBL;6.3.2.-;Casitas B-lineage lymphoma proto-oncogene;Proto-oncogene c-Cbl;RING finger protein 55;Signal transduction protein CBL;CBL;CBL2, RNF55;
Tissue Specificity	Mostly in endothelial cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P22681
Gene Name	CBL
Sequence	Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.
Subcellular Location	Cytoplasm. Cell membrane. Colocalizes with FGFR2 in lipid rafts at the cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Joazeiro, C. A. P., Wing, S. S., Huang, H., Leverson, J. D., Hunter, T., Liu, Y.-C. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286: 309-312, 1999. <br /><br />2. Martinelli, S., De Luca, A., Stellacci, E., Rossi, C., Checquolo, S., Lepri, F., Caputo, V., Silvano, M., Buscherini, F., Consoli, F., Ferrara, G., Digilio, M. C., and 14 others.Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype. Am. J. Hum. Genet. 87: 250-257, 2010. <br /><br />3. Wei, S., Rocchi, M., Archidiacono, N., Sacchi, N., Romeo, G., Gatti, R. A. Physical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus. Cancer Genet. Cytogenet. 46: 1-8, 1990. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007069-1	PA1800	-	100 ug	$370		Add to Cart
BHA21007069-2	PA1800-10ug	Sample	10 ug	$99		Add to Cart
BHA21007069-3	PA1800-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007069-4	PA1800-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007069-5	PA1800-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007069-6	PA1800-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007069-7	PA1800-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007069-8	PA1800-FITC	FITC	100 ug	$570		Add to Cart
BHA21007069-9	PA1800-HRP	HRP	100 ug	$570		Add to Cart
BHA21007069-10	PA1800-APC	APC	100 ug	$670		Add to Cart
BHA21007069-11	PA1800-PE	PE	100 ug	$670		Add to Cart
BHA21007069-12	PA1800-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007069-13	PA1800-carrier-free	carrier-free	100 ug	$370		Add to Cart

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