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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Caveolin-2/CAV2 Antibody Picoband®

SKU : BHA21006873

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Mfr.No.	PA1540, PA1540-10ug, PA1540-Biotin, PA1540-Cy3, PA1540-Dylight488, PA1540-Dylight550, PA1540-Dylight594, PA1540-FITC, PA1540-HRP, PA1540-APC, PA1540-PE, PA1540-iFluor647, PA1540-carrier-free
Alternative Names	Caveolin-2
Background	Caveolin-2 is a protein related to caveolin-1 which is derived caveolin-enriched membranes. CAV2 and CAV1 are similar in most respects and they differ in their functional interactions with heterotrimeric G proteins. Caveolin-1 and caveolin-2 are expressed in neuronal cells. Caveolin-2 was upregulated in response to neuronal cell injury. The CAV2 gene is mapped to 7q31.1-q31.2. The CAV1 gene contains 3 exons, while the human CAV2 gene contains 2 exons. The boundary of the last exon of CAV1 and CAV2 are analogous, suggesting that they arose through gene duplication. The genes encoding murine caveolin-1 and -2 are colocalized within the A2 region of mouse chromosome 6.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Caveolin-2/CAV2 Antibody catalog # PA1540. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May act as a scaffolding protein within caveolar membranes. Interacts ly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae for
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Caveolin-2, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	17 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Caveolin-2;CAV2;
Tissue Specificity	Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P51636
Gene Name	CAV2
Sequence	Belongs to the caveolin family.
Subcellular Location	Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Scherer, P. E., Okamoto, T., Chun, M., Nishimoto, I., Lodish, H. F., Lisanti, M. P.Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.Proc. Nat. Acad. Sci. 93: 131-135, 1996. 2. Yamazaki, K., Mizui, Y., Tanaka, I.Radiation hybrid mapping of human ADAM10 gene to chromosome 15.Genomics 45: 457-459, 1997.<br /><br />2. Galbiati, F., Volonte, D., Gil, O., Zanazzi, G., Salzer, J. L., Sargiacomo, M., Scherer, P. E., Engelman, J. A., Schlegel, A., Parenti, M., Okamoto, T., Lisanti, M. P.Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury.Proc. Nat. Acad. Sci. 95: 10257-10262, 1998.<br /><br />3. Engelman, J. A., Zhang, X. L., Galbiati, F., Lisanti, M. P.Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3): Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/7q31).FEBS Lett. 429: 330-336, 1998.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006873-1	PA1540	-	100 ug	$370		Add to Cart
BHA21006873-2	PA1540-10ug	Sample	10 ug	$99		Add to Cart
BHA21006873-3	PA1540-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006873-4	PA1540-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006873-5	PA1540-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006873-6	PA1540-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006873-7	PA1540-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006873-8	PA1540-FITC	FITC	100 ug	$570		Add to Cart
BHA21006873-9	PA1540-HRP	HRP	100 ug	$570		Add to Cart
BHA21006873-10	PA1540-APC	APC	100 ug	$670		Add to Cart
BHA21006873-11	PA1540-PE	PE	100 ug	$670		Add to Cart
BHA21006873-12	PA1540-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006873-13	PA1540-carrier-free	carrier-free	100 ug	$370		Add to Cart

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