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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CaV1.3/CACNA1D Antibody Picoband®

SKU : BHA21000227

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Mfr.No.	PB9329, PB9329-10ug, PB9329-Biotin, PB9329-Cy3, PB9329-Dylight488, PB9329-Dylight550, PB9329-Dylight594, PB9329-FITC, PB9329-HRP, PB9329-APC, PB9329-PE, PB9329-iFluor647, PB9329-carrier-free
Alternative Names	Voltage-dependent L-type calcium channel subunit alpha-1D
Background	CACNA1D is also known as PASNA, SANDD or Cav1.3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is ed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CaV1.3/CACNA1D Antibody Picoband® catalog # PB9329. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell mo
Host	Rabbit
Immunogen Region	E.coli-derived human CaV1.3 recombinant protein (Position: M1-I180). Human CaV1.3 shares 99% and 98%amino acid (aa) sequence identity with mouse and rat CaV1.3, respectively.
Isotype	Rabbit IgG
Molecular Weight	245 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Voltage-dependent L-type calcium channel subunit alpha-1D;Calcium channel, L type, alpha-1 polypeptide, isoform 2;Voltage-gated calcium channel subunit alpha Cav1.3;CACNA1D;CACH3, CACN4, CACNL1A2, CCHL1A2;
Tissue Specificity	Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q01668
Gene Id	776
Gene Name	CACNA1D
Subcellular Location	Membrane ; Multi-pass membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human Immunocytochemistry, 0.5-1ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Lieb A, et al. C-terminal modulatory domain controls coupling of voltage-sensing to pore opening in Cav1.3 L-type Ca(2+) channels. Biophys J, 2014 Apr 1. 2. Scholl UI, et al. Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nat Genet, 2013 Sep.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000227-1	PB9329	100 ug	-	$370		Add to Cart
BHA21000227-2	PB9329-10ug	10 ug	Sample	$99		Add to Cart
BHA21000227-3	PB9329-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000227-4	PB9329-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000227-5	PB9329-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000227-6	PB9329-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000227-7	PB9329-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000227-8	PB9329-FITC	100 ug	FITC	$570		Add to Cart
BHA21000227-9	PB9329-HRP	100 ug	HRP	$570		Add to Cart
BHA21000227-10	PB9329-APC	100 ug	APC	$670		Add to Cart
BHA21000227-11	PB9329-PE	100 ug	PE	$670		Add to Cart
BHA21000227-12	PB9329-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000227-13	PB9329-carrier-free	100 ug	carrier-free	$370		Add to Cart

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