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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cathepsin L/MEP/Ctsl Antibody Picoband®

SKU : BHA21004021

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Mfr.No.	A01589-3, A01589-3-10ug, A01589-3-Biotin, A01589-3-Cy3, A01589-3-Dylight488, A01589-3-Dylight550, A01589-3-Dylight594, A01589-3-FITC, A01589-3-HRP, A01589-3-APC, A01589-3-PE, A01589-3-iFluor647, A01589-3-carrier-free
Alternative Names	neutrophil cytosolic factor 1
Background	The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cathepsin L/MEP/Ctsl Antibody Picoband® catalog # A01589-3. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of mouse Cathepsin L/MEP/Ctsl, which shares 70% and 95% amino acid (aa) sequence identity with human CTSL, respectively.
Isotype	Rabbit IgG
Molecular Weight	20-42 kDa
Reactivity	Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox; NCF1; NOXO2; SH3PXD1A
Tissue Specificity	Detected in peripheral blood monocytes and neutrophils (at protein level).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P06797
Gene Id	13039
Gene Name	Ctsl
Subcellular Location	Cytoplasm, cytosol.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	Flow Cytometry, IHC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Mouse<br>

Reference	1. Abudula, A., Rommerskirch, W., Weber, E., Gunther, D., Wiederanders, B. Splice variants of human cathepsin L mRNA show different expression rates. Biol. Chem. 382: 1583-1591, 2001. <br /><br />2. Arora, S., Chauhan, S. S. Identification and characterization of a novel human cathepsin L splice variant. Gene 293: 123-131, 2002. <br /><br />3. Bakhshi, R., Goel, A., Seth, P., Chhikara, P., Chauhan, S. S. Cloning and characterization of human cathepsin L promoter. Gene 275: 93-101, 2001.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004021-1	A01589-3	-	100 ug	$370		Add to Cart
BHA21004021-2	A01589-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21004021-3	A01589-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004021-4	A01589-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004021-5	A01589-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004021-6	A01589-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004021-7	A01589-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004021-8	A01589-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21004021-9	A01589-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21004021-10	A01589-3-APC	APC	100 ug	$670		Add to Cart
BHA21004021-11	A01589-3-PE	PE	100 ug	$670		Add to Cart
BHA21004021-12	A01589-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004021-13	A01589-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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