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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cathepsin K/CTSK Antibody Picoband®

SKU : BHA21000758

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Mfr.No.	PB9856, PB9856-10ug, PB9856-Biotin, PB9856-Cy3, PB9856-Dylight488, PB9856-Dylight550, PB9856-Dylight594, PB9856-FITC, PB9856-HRP, PB9856-APC, PB9856-PE, PB9856-iFluor647, PB9856-carrier-free
Alternative Names	Cathepsin K
Background	Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene. It is mapped to 1q21. The protein encoded by this gene is a lysosomal cysteine protease involved in bone remodeling and resorption. And this protein, which is a member of the peptidase C1 protein family, is expressed predominantly in osteoclasts. Additionally, the enzyme's ability to catabolize elastin, collagen, and gelatin allow it to break down bone and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil inemphysema. Cathepsin K inhibitors, such as odanacatib, show great potential in the treatment of osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cathepsin K/CTSK Antibody Picoband® catalog # PB9856. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
Host	Rabbit
Immunogen Region	E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.
Isotype	Rabbit IgG
Molecular Weight	45 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cathepsin K;3.4.22.38;Cathepsin O;Cathepsin O2;Cathepsin X;CTSK;CTSO, CTSO2;
Tissue Specificity	Predominantly expressed in osteoclasts (bones).
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P43235
Gene Id	1513
Gene Name	CTSK
Subcellular Location	Lysosome.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. "Entrez Gene: CTSK cathepsin K". 2. Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T (January 1995). "Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone". Biochem. Biophys. Res. Commun. 206 (1): 8996. 3. Motyckova G, Fisher DE (2003). "Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease.". Curr. Mol. Med. 2 (5): 40721.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000758-1	PB9856	100 ug	-	$370		Add to Cart
BHA21000758-2	PB9856-10ug	10 ug	Sample	$99		Add to Cart
BHA21000758-3	PB9856-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000758-4	PB9856-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000758-5	PB9856-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000758-6	PB9856-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000758-7	PB9856-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000758-8	PB9856-FITC	100 ug	FITC	$570		Add to Cart
BHA21000758-9	PB9856-HRP	100 ug	HRP	$570		Add to Cart
BHA21000758-10	PB9856-APC	100 ug	APC	$670		Add to Cart
BHA21000758-11	PB9856-PE	100 ug	PE	$670		Add to Cart
BHA21000758-12	PB9856-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000758-13	PB9856-carrier-free	100 ug	carrier-free	$370		Add to Cart

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