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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cathepsin D/CTSD Antibody Picoband®

SKU : BHA21000756

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Mfr.No.	PB9854, PB9854-10ug, PB9854-Biotin, PB9854-Cy3, PB9854-Dylight488, PB9854-Dylight550, PB9854-Dylight594, PB9854-FITC, PB9854-HRP, PB9854-APC, PB9854-PE, PB9854-iFluor647, PB9854-carrier-free
Alternative Names	Cathepsin D
Background	Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease and it has been considered as a breast cancer tumor marker.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cathepsin D/CTSD Antibody Picoband® catalog # PB9854. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Host	Rabbit
Immunogen Region	E.coli-derived human Cathepsin D recombinant protein (Position: M201-L412). Human Cathepsin D shares 84.4% and 84% amino acid (aa) sequence identity with mouse and rat Cathepsin D, respectively.
Isotype	Rabbit IgG
Molecular Weight	28, 45 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cathepsin D;3.4.23.5;Cathepsin D light chain;Cathepsin D heavy chain;CTSD;CPSD;
Tissue Specificity	Expressed in the aorta extrcellular space (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P07339
Gene Id	1509
Gene Name	CTSD
Subcellular Location	Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Faust PL, Kofeld S, Chirgwin JM (Sep 1985). "Cloning and sequence analysis of cDNA for human cathepsin D". Proc Natl Acad Sci U S A 82 (15): 49104. 2. Wolf M, Clark-Lewis I, Buri C, Langen H, Lis M, Mazzucchelli L (April 2003). "Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer". Am. J. Pathol. 162 (4): 118390.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000756-1	PB9854	100 ug	-	$370		Add to Cart
BHA21000756-2	PB9854-10ug	10 ug	Sample	$99		Add to Cart
BHA21000756-3	PB9854-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000756-4	PB9854-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000756-5	PB9854-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000756-6	PB9854-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000756-7	PB9854-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000756-8	PB9854-FITC	100 ug	FITC	$570		Add to Cart
BHA21000756-9	PB9854-HRP	100 ug	HRP	$570		Add to Cart
BHA21000756-10	PB9854-APC	100 ug	APC	$670		Add to Cart
BHA21000756-11	PB9854-PE	100 ug	PE	$670		Add to Cart
BHA21000756-12	PB9854-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000756-13	PB9854-carrier-free	100 ug	carrier-free	$370		Add to Cart

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