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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cathepsin D/CTSD Antibody Picoband®

SKU : BHA21007508

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Mfr.No.	PB9048, PB9048-10ug, PB9048-Biotin, PB9048-Cy3, PB9048-Dylight488, PB9048-Dylight550, PB9048-Dylight594, PB9048-FITC, PB9048-HRP, PB9048-APC, PB9048-PE, PB9048-iFluor647, PB9048-carrier-free
Alternative Names	Cathepsin D
Background	Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease and it has been considered as a breast cancer tumor marker.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cathepsin D/CTSD Antibody Picoband® catalog # PB9048. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Acid protease active in intracellular protein breakdown.
Host	Rabbit
Immunogen Region	E.coli-derived mouse Cathepsin D recombinant protein (Position: E65-L410). Mouse Cathepsin D shares 85% and 91% amino acid (aa) sequences identity with human and rat Cathepsin D, respectively.
Isotype	Rabbit IgG
Molecular Weight	45 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cathepsin D;3.4.23.5;Ctsd;
Tissue Specificity	Expressed in the aorta extrcellular space (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P18242
Gene Id	13033
Gene Name	CTSD
Sequence	Belongs to the peptidase A1 family.
Subcellular Location	Lysosome. Melanosome . Secreted, extracellular space .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Mouse

Reference	1. Faust PL, Kofeld S, Chirgwin JM (Sep 1985). "Cloning and sequence analysis of cDNA for human cathepsin D". Proc Natl Acad Sci U S A 82 (15): 49104. 2. Wolf M, Clark-Lewis I, Buri C, Langen H, Lis M, Mazzucchelli L (April 2003). "Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer". Am. J. Pathol. 162 (4): 118390.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007508-1	PB9048	-	100 ug	$370		Add to Cart
BHA21007508-2	PB9048-10ug	Sample	10 ug	$99		Add to Cart
BHA21007508-3	PB9048-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007508-4	PB9048-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007508-5	PB9048-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007508-6	PB9048-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007508-7	PB9048-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007508-8	PB9048-FITC	FITC	100 ug	$570		Add to Cart
BHA21007508-9	PB9048-HRP	HRP	100 ug	$570		Add to Cart
BHA21007508-10	PB9048-APC	APC	100 ug	$670		Add to Cart
BHA21007508-11	PB9048-PE	PE	100 ug	$670		Add to Cart
BHA21007508-12	PB9048-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007508-13	PB9048-carrier-free	carrier-free	100 ug	$370		Add to Cart

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