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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Caspase-8 (P18)/CASP8 Antibody Picoband®

SKU : BHA21006705

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Mfr.No.	PA1308, PA1308-10ug, PA1308-Biotin, PA1308-Cy3, PA1308-Dylight488, PA1308-Dylight550, PA1308-Dylight594, PA1308-FITC, PA1308-HRP, PA1308-APC, PA1308-PE, PA1308-iFluor647, PA1308-carrier-free
Alternative Names	Caspase-8
Background	Caspase 8 is a caspase protein. It most likely acts upon caspase 3. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. The human CASP8 gene, whose product is also known as caspase 8 and FLICE, encodes an interleukin-1beta converting enzyme (ICE)-related cysteine protease that is activated by the engagement of several different death receptors. Caspase 8 is immediately recruited to the Fas receptor once it oligomerizes, and its protease activity is crucial for the apoptotic response generated by the resulting death-inducing signaling complex (DISC). This gene contains at least 11 exons spanning approximately 30kb on human chromosome band 2q33-34. This region of human chromosome 2 was previously reported as the location of the CASP10 gene, whose product is closely related to caspase 8. Caspase-8 deficiency in humans is compatible with normal development and shows that caspase-8 has a postnatal role in immune activation of naive lymphocytes.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Caspase-8 (P18)/CASP8 Antibody catalog # PA1308. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing sign
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Caspase-8(P18), different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Caspase-8;CASP-8;3.4.22.61;Apoptotic cysteine protease;Apoptotic protease Mch-5;CAP4;FADD-homologous ICE/ced-3-like protease;FADD-like ICE;FLICE;ICE-like apoptotic protease 5;MORT1-associated ced-3 homolog;MACH;Caspase-8 subunit p18;Caspase-8 subunit p10;CASP8;MCH5;
Tissue Specificity	Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q14790
Gene Name	CASP8
Sequence	Belongs to the peptidase C14A family.
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Grenet, J.; Teitz, T.; Wei, T.; Valentine, V.; Kidd, V. J. : Structure and chromosome localization of the human CASP8 gene. Gene 226: 225-232, 1999. <br /><br />2. Chun, H. J.; Zheng, L.; Ahmad, M.; Wang, J.; Speirs, C. K.; Siegel, R. M.; Dale, J. K.; Puck, J.; Davis, J.; Hall, C. G.; Skoda-Smith, S.; Atkinson, T. P.; Straus, S. E.; Lenardo, M. J. : Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 419: 395-399, 2002.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006705-1	PA1308	-	100 ug	$370		Add to Cart
BHA21006705-2	PA1308-10ug	Sample	10 ug	$99		Add to Cart
BHA21006705-3	PA1308-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006705-4	PA1308-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006705-5	PA1308-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006705-6	PA1308-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006705-7	PA1308-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006705-8	PA1308-FITC	FITC	100 ug	$570		Add to Cart
BHA21006705-9	PA1308-HRP	HRP	100 ug	$570		Add to Cart
BHA21006705-10	PA1308-APC	APC	100 ug	$670		Add to Cart
BHA21006705-11	PA1308-PE	PE	100 ug	$670		Add to Cart
BHA21006705-12	PA1308-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006705-13	PA1308-carrier-free	carrier-free	100 ug	$370		Add to Cart

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