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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Caspase-3(p17)/CASP3 Antibody Picoband®

SKU : BHA21003996

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Mfr.No.	A00334-2, A00334-2-10ug, A00334-2-Biotin, A00334-2-Cy3, A00334-2-Dylight488, A00334-2-Dylight550, A00334-2-Dylight594, A00334-2-FITC, A00334-2-HRP, A00334-2-APC, A00334-2-PE, A00334-2-iFluor647, A00334-2-carrier-free
Alternative Names	menin 1
Background	Caspase 3 is a caspase protein which interacts with Survivin, XIAP, CFLAR, Caspase 8, HCLS1, Deleted in Colorectal Cancer, TRAF3 and GroEL. This gene which is located on 4q35 encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. And the caspase-3 activation in heart failure sequentially cleaves SRF and generates a truncated SRF that appears to function as a dominant-negative transcription factor. Additionally, the caspase-3 influence on bone mineral absorbance should be considered in any in vivo application of caspase-3 inhibitors to the treatment of human disease. In erythroid precursors undergoing terminal differentiation, Hsp70 prevents active CASP3 from cleaving GATA1 and inducing apoptosis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Caspase-3(p17)/CASP3 Antibody Picoband® catalog # A00334-2. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Caspase-3(p17)/CASP3, which shares 78.3% and 87% amino acid (aa) sequence identity with mouse and rat CASP3.
Isotype	Rabbit IgG
Molecular Weight	32 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Menin; MEN1; SCG2
Tissue Specificity	Expressed in the islets of Langerhans (at protein level).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P42574
Gene Id	836
Gene Name	CASP3
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. Chang, J.; Wei, L.; Otani, T.; Youker, K. A.; Entman, M. L.; Schwartz, R. J. : Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading. Circulation 108: 407-413, 2003. 2. Miura, M.; Chen, X.-D.; Allen, M. R.; Bi, Y.; Gronthos, S.; Seo, B.-M.; Lakhani, S.; Flavell, R. A.; Feng, X.-H.; Robey, P. G.; Young, M.; Shi, S. : A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. J. Clin. Invest. 114: 1704-1713, 2004. 3. Ribeil, J.-A.; Zermati, Y.; Vandekerckhove, J.; Cathelin, S.; Kersual, J.; Dussiot, M.; Coulon, S.; Moura, I. C.; Zeuner, A.; Kirkegaard-Sorensen, T.; Varet, B.; Solary, E.; Garrido, C.; Hermine, O. : Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature 445: 102-105, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003996-1	A00334-2	-	100 ug	$370		Add to Cart
BHA21003996-2	A00334-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003996-3	A00334-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003996-4	A00334-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003996-5	A00334-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003996-6	A00334-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003996-7	A00334-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003996-8	A00334-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003996-9	A00334-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003996-10	A00334-2-APC	APC	100 ug	$670		Add to Cart
BHA21003996-11	A00334-2-PE	PE	100 ug	$670		Add to Cart
BHA21003996-12	A00334-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003996-13	A00334-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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