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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Caspase-12/CASP12 Antibody Picoband®

SKU : BHA21007308

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Mfr.No.	PA2103, PA2103-10ug, PA2103-Biotin, PA2103-Cy3, PA2103-Dylight488, PA2103-Dylight550, PA2103-Dylight594, PA2103-FITC, PA2103-HRP, PA2103-APC, PA2103-PE, PA2103-iFluor647, PA2103-carrier-free
Alternative Names	Inactive caspase-12
Background	Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Csp12L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of CSP12L expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Caspase-12/CASP12 Antibody catalog # PA2103. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-12.
Isotype	Rabbit IgG
Molecular Weight	39 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Inactive caspase-12;CASP-12;CASP12;UNQ9415/PRO34398;
Tissue Specificity	Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q6UXS9
Gene Name	CASP12
Sequence	Belongs to the peptidase C14A family.
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat<br>

Reference	1. Fischer, H., Koenig, U., Eckhart, L., Tschachler, E. Human caspase 12 has acquired deleterious mutations. Biochem. Biophys. Res. Commun. 293: 722-726, 2002.<br /><br />2. Saleh, M., Mathison, J. C., Wolinski, M. K., Bensinger, S. J., Fitzgerald, P., Droin, N., Ulevitch, R. J., Green D. R., Nicholson, D. W. Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 440: 1064-1068, 2006.<br /><br />3. Yeretssian, G., Doiron, K., Shao, W., Leavitt, B. R., Hayden, M. R., Nicholson, D. W., Saleh, M. Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection. Proc. Nat. Acad. Sci. 106: 9016-9020, 2009. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007308-1	PA2103	-	100 ug	$370		Add to Cart
BHA21007308-2	PA2103-10ug	Sample	10 ug	$99		Add to Cart
BHA21007308-3	PA2103-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007308-4	PA2103-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007308-5	PA2103-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007308-6	PA2103-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007308-7	PA2103-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007308-8	PA2103-FITC	FITC	100 ug	$570		Add to Cart
BHA21007308-9	PA2103-HRP	HRP	100 ug	$570		Add to Cart
BHA21007308-10	PA2103-APC	APC	100 ug	$670		Add to Cart
BHA21007308-11	PA2103-PE	PE	100 ug	$670		Add to Cart
BHA21007308-12	PA2103-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007308-13	PA2103-carrier-free	carrier-free	100 ug	$370		Add to Cart

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