JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Primary Antibodies / Polyclonal Antibodies

Anti-Caspase-10/CASP10 Antibody Picoband®

SKU : BHA21006854

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

Boster

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	PA1513, PA1513-10ug, PA1513-Biotin, PA1513-Cy3, PA1513-Dylight488, PA1513-Dylight550, PA1513-Dylight594, PA1513-FITC, PA1513-HRP, PA1513-APC, PA1513-PE, PA1513-iFluor647, PA1513-carrier-free
Alternative Names	Caspase-10
Background	Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene. The Caspase 10 gene contains 11 exons and spans about 48 kb. This gene is mapped to 2q33.1. It is transcribed in the centromere-to-telomere ion.This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alteatively spliced transcript variants encoding different isoforms have been described for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Caspase-10/CASP10 Antibody catalog # PA1513. Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7,
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human CASP10.
Isotype	Rabbit IgG
Molecular Weight	57 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Caspase-10;CASP-10;3.4.22.63;Apoptotic protease Mch-4;FAS-associated death domain protein interleukin-1B-converting enzyme 2;FLICE2;ICE-like apoptotic protease 4;Caspase-10 subunit p23/17;Caspase-10 subunit p12;CASP10;MCH4;
Tissue Specificity	Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.

Uniprot	Q92851
Gene Name	CASP10
Sequence	Belongs to the peptidase C14A family.
Subcellular Location	Cytoplasm. Nucleus. TLE3 promotes its nuclear localization.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Lee, H.-J., Pyo, J.-O., Oh, Y., Kim, H.-J., Hong, S., Jeon, Y.-J., Kim, H., Cho, D.-H., Woo, H.-N., Song, S., Nam, J.-H., Kim, H. J., Kim, K.-S., Jung, Y.-K.AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10.Nature Cell Biol. 9: 1303-1310, 2007.<br /><br />2. Park, W. S., Lee, J. H., Shin, M. S., Park, J. Y., Kim, H. S., Lee, J. H., Kim, Y. S., Lee, S. N., Xiao, W., Park, C. H., Lee, S. H., Yoo, N. J., Lee, J. Y.Inactivating mutations of the caspase-10 gene in gastric cancer.Oncogene 21: 2919-2925, 2002.<br /><br />3. Wang, J., Zheng, L., Lobito, A., Chan, F. K., Dale, J., Sneller, M., Yao, X., Puck, J. M., Straus, S. E., Lenardo, M. J.Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.Cell 98: 47-58, 1999.<br /><br />

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006854-1	PA1513	-	100 ug	$370		Add to Cart
BHA21006854-2	PA1513-10ug	Sample	10 ug	$99		Add to Cart
BHA21006854-3	PA1513-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006854-4	PA1513-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006854-5	PA1513-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006854-6	PA1513-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006854-7	PA1513-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006854-8	PA1513-FITC	FITC	100 ug	$570		Add to Cart
BHA21006854-9	PA1513-HRP	HRP	100 ug	$570		Add to Cart
BHA21006854-10	PA1513-APC	APC	100 ug	$670		Add to Cart
BHA21006854-11	PA1513-PE	PE	100 ug	$670		Add to Cart
BHA21006854-12	PA1513-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006854-13	PA1513-carrier-free	carrier-free	100 ug	$370		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.