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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Carboxypeptidase B2/CPB2 Antibody Picoband®

SKU : BHA21000902

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Mfr.No.	PB9997, PB9997-10ug, PB9997-Biotin, PB9997-Cy3, PB9997-Dylight488, PB9997-Dylight550, PB9997-Dylight594, PB9997-FITC, PB9997-HRP, PB9997-APC, PB9997-PE, PB9997-iFluor647, PB9997-carrier-free
Alternative Names	Carboxypeptidase B2
Background	Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Carboxypeptidase B2/CPB2 Antibody Picoband® catalog # PB9997. Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that
Host	Rabbit
Immunogen Region	E. coli-derived human CPB2 recombinant protein (Position: K166-D388). Human CPB2 shares 86.1% and 85.7% amino acid (aa) sequence identity with mouse and rat CPB2, respectively.
Isotype	Rabbit IgG
Molecular Weight	48 kDa, 60 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Carboxypeptidase B2;3.4.17.20 ;Carboxypeptidase U;CPU;Plasma carboxypeptidase B;pCPB;Thrombin-activable fibrinolysis inhibitor;TAFI;CPB2;
Tissue Specificity	Plasma; synthesized in the liver.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q96IY4
Gene Id	1361
Gene Name	CPB2
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat ELISA(Cap) , 1-5ug/ml, Human, -

Reference	1. Boffa MB, Reid TS, Joo E, Nesheim ME, Koschinsky ML (May 1999). "Characterization of the gene encoding human TAFI (thrombin-activable fibrinolysis inhibitor; plasma procarboxypeptidase B)". Biochemistry 38 (20): 654758. 2. Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D (Dec 1991). "Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma". J Biol Chem 266 (32): 218338. 3. Tsai SP, Drayna D (Dec 1992). "The gene encoding human plasma carboxypeptidase B (CPB2) resides on chromosome 13". Genomics14 (2): 54950.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000902-1	PB9997	100 ug	-	$370		Add to Cart
BHA21000902-2	PB9997-10ug	10 ug	Sample	$99		Add to Cart
BHA21000902-3	PB9997-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000902-4	PB9997-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000902-5	PB9997-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000902-6	PB9997-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000902-7	PB9997-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000902-8	PB9997-FITC	100 ug	FITC	$570		Add to Cart
BHA21000902-9	PB9997-HRP	100 ug	HRP	$570		Add to Cart
BHA21000902-10	PB9997-APC	100 ug	APC	$670		Add to Cart
BHA21000902-11	PB9997-PE	100 ug	PE	$670		Add to Cart
BHA21000902-12	PB9997-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000902-13	PB9997-carrier-free	100 ug	carrier-free	$370		Add to Cart

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