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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Canstatin Antibody Picoband®

SKU : BHA21006860

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Mfr.No.	PA1521, PA1521-10ug, PA1521-Biotin, PA1521-Cy3, PA1521-Dylight488, PA1521-Dylight550, PA1521-Dylight594, PA1521-FITC, PA1521-HRP, PA1521-APC, PA1521-PE, PA1521-iFluor647, PA1521-carrier-free
Alternative Names	Collagen alpha-2(IV) chain
Background	Canstatin, a cleavage product corresponding to the collagen alpha 2 (IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Canstatin Antibody catalog # PA1521. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and in
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Canstatin, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	56 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Collagen alpha-2 (IV) chain;Canstatin;COL4A2;
Tissue Specificity	Widely expressed. Differentially expressed in various brain regions. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P08572
Gene Name	COL4A2
Sequence	Belongs to the type IV collagen family.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat<br>

Reference	1. Hwang-Bo J, Hyun Yoo K, Park JH, Jeong HS, Chung IS.:Recombinant canstatin inhibits angiopoietin-1-induced angiogenesis and lymphangiogenesis. Int J Cancer. 2011 Aug 5.<br /><br />2. Hwang-Bo J, Yoo KH, Jeong HS, Chung IS.Recombinant canstatin inhibits tumor growth in an orthotopic AT-84 oral squamous cell carcinoma model. Biotechnol Lett. 2010 Feb;32(2):189-94. Epub 2009 Oct 17.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006860-1	PA1521	-	100 ug	$370		Add to Cart
BHA21006860-2	PA1521-10ug	Sample	10 ug	$99		Add to Cart
BHA21006860-3	PA1521-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006860-4	PA1521-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006860-5	PA1521-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006860-6	PA1521-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006860-7	PA1521-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006860-8	PA1521-FITC	FITC	100 ug	$570		Add to Cart
BHA21006860-9	PA1521-HRP	HRP	100 ug	$570		Add to Cart
BHA21006860-10	PA1521-APC	APC	100 ug	$670		Add to Cart
BHA21006860-11	PA1521-PE	PE	100 ug	$670		Add to Cart
BHA21006860-12	PA1521-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006860-13	PA1521-carrier-free	carrier-free	100 ug	$370		Add to Cart

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