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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Calpastatin/CAST Antibody Picoband®

SKU : BHA21001023

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Mfr.No.	A00337, A00337-10ug, A00337-Biotin, A00337-Cy3, A00337-Dylight488, A00337-Dylight550, A00337-Dylight594, A00337-FITC, A00337-HRP, A00337-APC, A00337-PE, A00337-iFluor647, A00337-carrier-free
Alternative Names	Calpastatin
Background	Calpastatin is a protein that in humans is encoded by the CAST gene. It is mapped to 5q15. The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alteatively spliced transcript variants encoding different isoforms have been described.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Calpastatin/CAST Antibody Picoband® catalog # A00337. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Calpastatin, different from the related mouse sequence by fifteen amino acids, and from the related rat sequence by eleven amino acids.
Isotype	Rabbit IgG
Molecular Weight	120 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Calpastatin;Calpain inhibitor;Sperm BS-17 component;CAST;
Tissue Specificity	Expressed in the islets of Langerhans (at protein level).
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P20810
Gene Id	831
Gene Name	CAST
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human

Reference	1. Avea M, De Tullio R, Capini P, Salamino F, Pontremoli S, Melloni E (Dec 2003). "Changes in calpastatin localization and expression during calpain activation: a new mechanism for the regulation of intracellular Ca(2+)-dependent proteolysis". Cell Mol Life Sci. 60 (12): 266978.<br /><br />2. Ma H, Yang HQ, Takano E, Lee WJ, Hatanaka M, Maki M (Sep 1993). "Requirement of different subdomains of calpastatin for calpain inhibition and for binding to calmodulin-like domains". J Biochem. 113 (5): 5919.<br /><br />3. Raynaud P, Jayat-Vignoles C, Laforet MP, Leveziel H, Amarger V (Apr 2005). "Four promoters expression of the calpastatin gene". Arch Biochem Biophys. 437 (1): 6977.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001023-1	A00337	100 ug	-	$370		Add to Cart
BHA21001023-2	A00337-10ug	10 ug	Sample	$99		Add to Cart
BHA21001023-3	A00337-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001023-4	A00337-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001023-5	A00337-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001023-6	A00337-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001023-7	A00337-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001023-8	A00337-FITC	100 ug	FITC	$570		Add to Cart
BHA21001023-9	A00337-HRP	100 ug	HRP	$570		Add to Cart
BHA21001023-10	A00337-APC	100 ug	APC	$670		Add to Cart
BHA21001023-11	A00337-PE	100 ug	PE	$670		Add to Cart
BHA21001023-12	A00337-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001023-13	A00337-carrier-free	100 ug	carrier-free	$370		Add to Cart

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