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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CA12 Antibody Picoband®

SKU : BHA21002397

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Mfr.No.	A04063-1, A04063-1-10ug, A04063-1-Biotin, A04063-1-Cy3, A04063-1-Dylight488, A04063-1-Dylight550, A04063-1-Dylight594, A04063-1-FITC, A04063-1-HRP, A04063-1-APC, A04063-1-PE, A04063-1-iFluor647, A04063-1-carrier-free
Alternative Names	carbonic anhydrase 12
Background	Carbonic anhydrase 12 is an enzyme that in humans is encoded by the CA12 gene. It is mapped to 15q22.2. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CA12 Antibody Picoband® catalog # A04063-1. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Reversible hydration of carbon dioxide.
Host	Rabbit
Immunogen Region	E.coli-derived human CA12 recombinant protein (Position: K45-A298).
Isotype	Rabbit IgG
Molecular Weight	45 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Carbonic anhydrase 12; Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII; Tumor antigen HOM-RCC-3.1.3; CA12
Tissue Specificity	Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Expressed in sweat glands and bronchiolar epithelium (PubMed:26911677).
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O43570
Gene Id	771
Gene Name	CA12
Subcellular Location	Cell membrane; Membrane; Single-pass type I membrane protein

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, WB
Description	"Weste blot, 0.25-0.5ug/ml, Human<br> ELISA, 0.1-0.5ug/ml, -<br>"

Reference	1. Hong, JH; Muhammad, E; Zheng, C; Hershkovitz, E; Alkrinawi, S; Loewenthal, N; Parvari, R; Muallem, S (15 December 2015). "Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation". The Joual of Physiology. 593 (24): 5299312. <br /><br />2. Lee, M; Vecchio-Pagán, B; Sharma, N; Waheed, A; Li, X; Raraigh, KS; Robbins, S; Han, ST; Franca, AL; Pellicore, MJ; Evans, TA; Arcara, KM; Nguyen, H; Luan, S; Belchis, D; Hertecant, J; Zabner, J; Sly, WS; Cutting, GR (23 February 2016). "Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease". Human Molecular Genetics. 25 (10): 19231933. <br /><br />3. Almståhl, A; Wikström, M (May 2003). "Electrolytes in stimulated whole saliva in individuals with hyposalivation of different origins". Archives of Oral Biology. 48 (5): 33744. doi:10.1016/s0003-9969(02)00200-5. PMID 12711377.<br /><br /> Manokaran, S; Zhang, X; Chen, W; Srivastava, DK (June 2010). "Differential modulation of the active site environment of human carbonic anhydrase XII by cationic quantum dots and polylysine". Biochimica et Biophysica Acta. 1804 (6): 137684.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002397-1	A04063-1	-	100 ug	$370		Add to Cart
BHA21002397-2	A04063-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002397-3	A04063-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002397-4	A04063-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002397-5	A04063-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002397-6	A04063-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002397-7	A04063-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002397-8	A04063-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002397-9	A04063-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002397-10	A04063-1-APC	APC	100 ug	$670		Add to Cart
BHA21002397-11	A04063-1-PE	PE	100 ug	$670		Add to Cart
BHA21002397-12	A04063-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002397-13	A04063-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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