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Home / Primary Antibodies / Polyclonal Antibodies

Anti-c-Myc Antibody Picoband®

SKU : BHA21000004

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Mfr.No.	PB9092, PB9092-10ug, PB9092-Biotin, PB9092-Cy3, PB9092-Dylight488, PB9092-Dylight550, PB9092-Dylight594, PB9092-FITC, PB9092-HRP, PB9092-APC, PB9092-PE, PB9092-iFluor647, PB9092-carrier-free
Alternative Names	Myc proto-oncogene protein
Background	C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. C-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-c-Myc Antibody Picoband® catalog # PB9092. Tested in IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC(GA)TG-3'. Activates the transcription of growth-related genes.
Host	Rabbit
Immunogen Region	E.coli-derived human c-Myc recombinant protein (Position: E257-A439). Human c-Myc shares 91% amino acid (aa) sequences identity with both mouse and rat c-Myc.
Isotype	Rabbit IgG
Molecular Weight	60-65 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Myc proto-oncogene protein;Class E basic helix-loop-helix protein 39;bHLHe39;Proto-oncogene c-Myc;Transcription factor p64;MYC;BHLHE39;
Tissue Specificity	Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex- opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra- striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non- neuronal cells. Isoform APP751 is the most abundant form in T- lymphocytes. Appican is expressed in astrocytes. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P01106
Gene Id	4609
Gene Name	MYC
Sequence	Contains 1 bHLH (basic helix-loop-helix) domain.
Subcellular Location	Nucleus, nucleoplasm . Nucleus, nucleolus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human

Reference	1. Liao D, Thakur A, Wu J, Biliran H, Sarkar FH. Perspectives on c-Myc, Cyclin D1, and Their Interaction in Cancer Formation, Progression, and Response to Chemotherapy.Crit Rev Oncog. 2007;13(2):93-158. 2. Britton S, Salles B, Calsou P. c-MYC protein is degraded in response to UV irradiation.Cell Cycle. 2007 Oct 2;7(1) 3. Chow JM, Liu CR, Lin CP, Lee CN, Cheng YC, Lin S, Liu HE. Downregulation of c-Myc determines sensitivity to 2-methoxyestradiol-induced apoptosis in human acute myeloid leukemia.Exp Hematol. 2008 Feb;36(2):140-8. 4. Huang CY, Bredemeyer AL, Walker LM, Bassing CH, Sleckman BP. Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse.Eur J Immunol. 2008 Jan 14.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000004-1	PB9092	100 ug	-	$370		Add to Cart
BHA21000004-3	PB9092-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000004-4	PB9092-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000004-5	PB9092-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000004-6	PB9092-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000004-7	PB9092-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000004-8	PB9092-FITC	100 ug	FITC	$570		Add to Cart
BHA21000004-9	PB9092-HRP	100 ug	HRP	$570		Add to Cart
BHA21000004-10	PB9092-APC	100 ug	APC	$670		Add to Cart
BHA21000004-11	PB9092-PE	100 ug	PE	$670		Add to Cart
BHA21000004-12	PB9092-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000004-13	PB9092-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000004-2	PB9092-10ug	10 ug	Sample	$99		Add to Cart

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