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Home / Primary Antibodies / Polyclonal Antibodies

Anti-C-C chemokine receptor type 5 CCR5 Antibody Picoband®

SKU : BHA21006615

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Mfr.No.	PA1016, PA1016-10ug, PA1016-Biotin, PA1016-Cy3, PA1016-Dylight488, PA1016-Dylight550, PA1016-Dylight594, PA1016-FITC, PA1016-HRP, PA1016-APC, PA1016-PE, PA1016-iFluor647, PA1016-carrier-free
Alternative Names	C-C chemokine receptor type 5
Background	Human CC chemokine receptor 5 (CCR5), which is 17.5 kb from the CMKBR2 gene, encodes a 352-amino acid protein with a calculated molecular mass of 40,600 Da. It is organized into four exons and two introns. Human CCR5 is a co-receptor for macrophage-tropic strains of human immunodeficiency virus (HIV)-1 and is expressed by bone-marrow-derived cells. CCR5 is expressed on neurons, astrocytes, and microglia in the central nervous system, and on epithelium, endothelium, vascular smooth muscle and fibroblasts in other tissues. Functionally, CCR5 mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-C-C chemokine receptor type 5 CCR5 Antibody catalog # PA1016. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation o
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human CCR5, different from the related rat sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	40 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	C-C chemokine receptor type 5;C-C CKR-5;CC-CKR-5;CCR-5;CCR5;CHEMR13;HIV-1 fusion coreceptor;CD195;CCR5;CMKBR5;
Tissue Specificity	Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P51681
Gene Name	CCR5
Sequence	Belongs to the G-protein coupled receptor 1 family.
Subcellular Location	Cell membrane ; Multi-pass membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry. 1996 Mar 19; 35(11):3362-7.<br /><br />2. Rottman JB, Ganley KP, Williams K, Wu L, Mackay CR, Ringler DJ. Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection. Am J Pathol. 1997 Nov; 151(5):1341-51.<br /><br />3. Mummidi S, Ahuja SS, McDaniel BL, Ahuja SK. The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5'-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J Biol Chem. 1997 Dec 5; 272(49):30662-71.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006615-1	PA1016	-	100 ug	$370		Add to Cart
BHA21006615-2	PA1016-10ug	Sample	10 ug	$99		Add to Cart
BHA21006615-3	PA1016-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006615-4	PA1016-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006615-5	PA1016-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006615-6	PA1016-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006615-7	PA1016-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006615-8	PA1016-FITC	FITC	100 ug	$570		Add to Cart
BHA21006615-9	PA1016-HRP	HRP	100 ug	$570		Add to Cart
BHA21006615-10	PA1016-APC	APC	100 ug	$670		Add to Cart
BHA21006615-11	PA1016-PE	PE	100 ug	$670		Add to Cart
BHA21006615-12	PA1016-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006615-13	PA1016-carrier-free	carrier-free	100 ug	$370		Add to Cart

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