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Home / Primary Antibodies / Polyclonal Antibodies

Anti-BRSK1 Antibody Picoband®

SKU : BHA21003529

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Mfr.No.	A05997-2, A05997-2-10ug, A05997-2-Biotin, A05997-2-Cy3, A05997-2-Dylight488, A05997-2-Dylight550, A05997-2-Dylight594, A05997-2-FITC, A05997-2-HRP, A05997-2-APC, A05997-2-PE, A05997-2-iFluor647, A05997-2-carrier-free
Alternative Names	solute carrier family 25 member 1
Background	BR serine/threonine kinase 1 is an enzyme that in humans is encoded by the BRSK1 gene. BRSK1 was initially identified as a mammalian homolog to the fission yeast S. pombe Cdr2, a mitosis-regulatory kinase and also shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-BRSK1 Antibody Picoband® catalog # A05997-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Impo
Host	Rabbit
Immunogen Region	E.coli-derived human BRSK1 recombinant protein (Position: E269-E321).
Isotype	Rabbit IgG
Molecular Weight	90 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Tricarboxylate transport protein, mitochondrial; Citrate transport protein; CTP; Solute carrier family 25 member 1; Tricarboxylate carrier protein; SLC25A1; SLC20A3
Tissue Specificity	Detected in brain. Detected at very much lower levels in heart, lung, placenta and skeletal muscle. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q8TDC3
Gene Id	84446
Gene Name	BRSK1
Subcellular Location	Mitochondrion inner membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.25 ug/ml, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Kishi, M., Pan, Y. A., Crump, J. G., Sanes, Y. R. Mammalian SAD kinases are required for neuronal polarization. Science 307: 929-932, 2005. 2. Nagase, T., Nakayama, M., Nakajima, D., Kikuno, R., Ohara, O. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003529-1	A05997-2	-	100 ug	$370		Add to Cart
BHA21003529-2	A05997-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003529-3	A05997-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003529-4	A05997-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003529-5	A05997-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003529-6	A05997-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003529-7	A05997-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003529-8	A05997-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003529-9	A05997-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003529-10	A05997-2-APC	APC	100 ug	$670		Add to Cart
BHA21003529-11	A05997-2-PE	PE	100 ug	$670		Add to Cart
BHA21003529-12	A05997-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003529-13	A05997-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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