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Home / Primary Antibodies / Polyclonal Antibodies

Anti-BRCA1 Antibody Picoband®

SKU : BHA21007478

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Mfr.No.	PB9015, PB9015-10ug, PB9015-Biotin, PB9015-Cy3, PB9015-Dylight488, PB9015-Dylight550, PB9015-Dylight594, PB9015-FITC, PB9015-HRP, PB9015-APC, PB9015-PE, PB9015-iFluor647, PB9015-carrier-free
Alternative Names	Breast cancer type 1 susceptibility protein
Background	BRCA1, also known as BRCC1, is a gene which mapping to 17q21.3. This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. In addition to it, BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth and that this function is compromised in breast cancer either by mutation or by alterations in gene expression.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-BRCA1 Antibody Picoband® catalog # PB9015. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of ot
Host	Rabbit
Immunogen Region	E.coli-derived human BRCA1 recombinant protein (Position: E1661-Y1863). Human BRCA1 shares 65% and 66% amino acid (aa) sequences identity with mouse and rat BRCA1, respectively.
Isotype	Rabbit IgG
Molecular Weight	290 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Breast cancer type 1 susceptibility protein;6.3.2.-;RING finger protein 53;BRCA1;RNF53;
Tissue Specificity	Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P38398
Gene Id	672
Gene Name	BRCA1
Sequence	Contains 2 BRCT domains.
Subcellular Location	Nucleus . Chromosome . Cytoplasm . Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex. Translocated to the cytoplasm during UV-induced apoptosis. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Mouse, Rat, By Heat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Lee, M.-H., Lahusen, T., Wang, R.-H., Xiao, C., Xu, X., Hwang, Y.-S., He, W.-W., Shi, Y., Deng, C.-X. Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation. Oncogene 31: 116-127, 2012. <br /><br />2. Thompson, M. E., Jensen, R. A., Obermiller, P. S., Page, D. L., Holt, J. T. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nature Genet. 9: 444-450, 1995. <br /><br />3. Wang, B., Hurov, K., Hofmann, K., Elledge, S. J. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 23: 729-739, 2009. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007478-1	PB9015	-	100 ug	$370		Add to Cart
BHA21007478-2	PB9015-10ug	Sample	10 ug	$99		Add to Cart
BHA21007478-3	PB9015-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007478-4	PB9015-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007478-5	PB9015-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007478-6	PB9015-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007478-7	PB9015-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007478-8	PB9015-FITC	FITC	100 ug	$570		Add to Cart
BHA21007478-9	PB9015-HRP	HRP	100 ug	$570		Add to Cart
BHA21007478-10	PB9015-APC	APC	100 ug	$670		Add to Cart
BHA21007478-11	PB9015-PE	PE	100 ug	$670		Add to Cart
BHA21007478-12	PB9015-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007478-13	PB9015-carrier-free	carrier-free	100 ug	$370		Add to Cart

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