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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Bonzo/CXCR6 Antibody Picoband®

SKU : BHA21007290

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Mfr.No.	PA2082, PA2082-10ug, PA2082-Biotin, PA2082-Cy3, PA2082-Dylight488, PA2082-Dylight550, PA2082-Dylight594, PA2082-FITC, PA2082-HRP, PA2082-APC, PA2082-PE, PA2082-iFluor647, PA2082-carrier-free
Alternative Names	C-X-C chemokine receptor type 6
Background	CXCR6 (Chemokine,CXC Motif, Receptor 6), also known as STRL33, is a protein that in humans is encoded by the CXCR6 gene. By Southe blot analysis of genomic DNA and somatic cell hybrid analysis, Liao et al. (1997) mapped the single-copy STRL33 gene to chromosome 3. Matloubian et al. (2000) found that human and mouse cells expressing CXCR6 showed a strong chemotactic response to CXCL16 but not to other chemokines. The authors concluded that CXCL16 and CXCR6 probably function in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp. Kim et al. (2001) concluded that CXCR6 may be important in the trafficking of effector T cells mediating type-1 inflammation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Bonzo/CXCR6 Antibody catalog # PA2082. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Bonzo, different from the related mouse and rat sequences by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	39 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	C-X-C chemokine receptor type 6;CXC-R6;CXCR-6;CDw186;G-protein coupled receptor STRL33;G-protein coupled receptor bonzo;CD186;CXCR6;BONZO, STRL33, TYMSTR;
Tissue Specificity	Expressed in lymphoid tissues and activated T cells.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.

Uniprot	O00574
Gene Name	CXCR6
Sequence	Belongs to the G-protein coupled receptor 1 family.
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Kim, C. H., Kunkel, E. J., Boisvert, J., Johnston, B., Campbell, J. J., Genovese, M. C., Greenberg, H. B., Butcher, E. C. Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. J. Clin. Invest. 107: 595-601, 2001.<br /><br />2. Liao, F., Alkhatib, G., Peden, K. W. C., Sharma, G., Berger, E. A., Farber, J. M. STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J. Exp. Med. 185: 2015-2023, 1997.<br /><br />3. Matloubian, M., David, A., Engel, S., Ryan, J. E., Cyster, J. G. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nature Immun. 1: 298-304, 2000.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007290-1	PA2082	-	100 ug	$370		Add to Cart
BHA21007290-2	PA2082-10ug	Sample	10 ug	$99		Add to Cart
BHA21007290-3	PA2082-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007290-4	PA2082-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007290-5	PA2082-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007290-6	PA2082-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007290-7	PA2082-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007290-8	PA2082-FITC	FITC	100 ug	$570		Add to Cart
BHA21007290-9	PA2082-HRP	HRP	100 ug	$570		Add to Cart
BHA21007290-10	PA2082-APC	APC	100 ug	$670		Add to Cart
BHA21007290-11	PA2082-PE	PE	100 ug	$670		Add to Cart
BHA21007290-12	PA2082-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007290-13	PA2082-carrier-free	carrier-free	100 ug	$370		Add to Cart

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