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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Bone Sialoprotein/IBSP Antibody Picoband®

SKU : BHA21007142

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Mfr.No.	PA1887, PA1887-10ug, PA1887-Biotin, PA1887-Cy3, PA1887-Dylight488, PA1887-Dylight550, PA1887-Dylight594, PA1887-FITC, PA1887-HRP, PA1887-APC, PA1887-PE, PA1887-iFluor647, PA1887-carrier-free
Alternative Names	Bone sialoprotein 2
Background	IBSP (integrin-binding sialoprotein) is also known as BSP. The protein encoded by this gene is a major structural protein of the bone matrix. Bone sialoprotein is an acidic glycoprotein of approximately 70 kD that undergoes extensive posttranslational modifications. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. The BSP gene is mapped to 4q22.1.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Bone Sialoprotein/IBSP Antibody catalog # PA1887. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse Bone Sialoprotein, different from the related rat sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	18 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Bone sialoprotein 2;Bone sialoprotein II;BSP II;Cell-binding sialoprotein;Integrin-binding sialoprotein;Ibsp;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg Thimerosal, 0.01mg NaN3.

Uniprot	Q61711
Gene Name	IBSP
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, By Heat<br>

Reference	1. Duncan EL, et al. Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral absorbance and fracture risk. PLoS Genet, 2011 Apr.<br /><br />2. Gordon JA, et al. Bone sialoprotein stimulates focal adhesion-related signaling pathways: role in migration and survival of breast and prostate cancer cells. J Cell Biochem, 2009 Aug 15.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007142-1	PA1887	-	100 ug	$370		Add to Cart
BHA21007142-2	PA1887-10ug	Sample	10 ug	$99		Add to Cart
BHA21007142-3	PA1887-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007142-4	PA1887-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007142-5	PA1887-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007142-6	PA1887-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007142-7	PA1887-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007142-8	PA1887-FITC	FITC	100 ug	$570		Add to Cart
BHA21007142-9	PA1887-HRP	HRP	100 ug	$570		Add to Cart
BHA21007142-10	PA1887-APC	APC	100 ug	$670		Add to Cart
BHA21007142-11	PA1887-PE	PE	100 ug	$670		Add to Cart
BHA21007142-12	PA1887-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007142-13	PA1887-carrier-free	carrier-free	100 ug	$370		Add to Cart

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