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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Bik Antibody Picoband®

SKU : BHA21000658

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Mfr.No.	PB9755, PB9755-10ug, PB9755-Biotin, PB9755-Cy3, PB9755-Dylight488, PB9755-Dylight550, PB9755-Dylight594, PB9755-FITC, PB9755-HRP, PB9755-APC, PB9755-PE, PB9755-iFluor647, PB9755-carrier-free
Alternative Names	Bcl-2-interacting killer
Background	Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene. This gene is mapped to 22q13.31. The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Bik Antibody Picoband® catalog # PB9755. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X (L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. .
Host	Rabbit
Immunogen Region	E.coli-derived human Bik recombinant protein (Position: M1-R123). Human Bik shares 42.3% amino acid (aa) sequence identity with mouse Bik.
Isotype	Rabbit IgG
Molecular Weight	22 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Bcl-2-interacting killer;Apoptosis inducer NBK;BIP1;BP4;BIK;NBK;
Tissue Specificity	Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q13323
Gene Id	638
Gene Name	BIK
Subcellular Location	Endomembrane system; Single-pass membrane protein. Mitochondrion membrane ; Single-pass membrane protein . Around the nuclear envelope, and in cytoplasmic membranes.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, ICC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human, Rat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human Immunocytochemistry, 0.5-1ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. "Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)". 2. Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery BJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ (Dec 1995). "Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins". Oncogene 11 (9): 19218. 3. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22".Nature 402 (6761): 48995.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000658-1	PB9755	100 ug	-	$370		Add to Cart
BHA21000658-2	PB9755-10ug	10 ug	Sample	$99		Add to Cart
BHA21000658-3	PB9755-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000658-4	PB9755-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000658-5	PB9755-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000658-6	PB9755-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000658-7	PB9755-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000658-8	PB9755-FITC	100 ug	FITC	$570		Add to Cart
BHA21000658-9	PB9755-HRP	100 ug	HRP	$570		Add to Cart
BHA21000658-10	PB9755-APC	100 ug	APC	$670		Add to Cart
BHA21000658-11	PB9755-PE	100 ug	PE	$670		Add to Cart
BHA21000658-12	PB9755-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000658-13	PB9755-carrier-free	100 ug	carrier-free	$370		Add to Cart

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