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Home / Primary Antibodies / Polyclonal Antibodies

Anti-beta1-Adrenergic Receptor (extracellular)- mFluor Violet 450 Antibody

SKU : BHA21300042

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Alomone Labs

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Mfr.No.	AAR-023-V, AAR-023-V_15 mcl, AAR-023-V_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	beta-Adrenergic receptors (betaAR) belong to the superfamily of G-protein coupled receptors (GPCRs). betaAR stimulation by the sympathetic nervous system or circulating catecholamines is involved in peripheral blood circulation, metabolic regulation, muscle contraction, and central neural activities. In the heart, acute betaAR stimulation serves as the most powerful means to regulate cardiac output in response to a fight-or-flight situation. There are three betaAR subtypes, beta1AR, beta2AR and beta3AR, in cardiac myocytes1. The receptors consist of seven membrane-spanning domains, three intra- and three extracellular loops, an extracellular N-terminal domain, and an intracellular C-terminal tail2. beta1AR is the predominant receptor subtype expressed in human cardiomyocytes. beta1AR is also expressed in the kidney3. It has been implicated in adipogenesis and memory formation4. beta1AR has been widely connected with heart disease. Both the downregulation and overstimulation of beta1AR have been connected to myocyte apoptosis. In addition, chronic heart failure is characterized by abnormalities in beta1AR signal transduction. It was demonstrated that heart failure is also inducible in animal models by overexpression of components of the beta1AR signal transduction cascade. Transgenic mice overexpressing beta1AR develop, with aging, heart failure similar to that observed in dilated cardiomyopathy in humans5.
Clonality	Polyclonal
Description	Anti-beta1-Adrenergic Receptor (extracellular) Antibody (#AAR-023) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry and indirect live cell flow cytometry applications. It has been designed to recognize beta1-Adrenergic Receptor from rat, mouse, and human samples. Anti-beta1-Adrenergic Receptor (extracellular)- mFluor Violet 450 Antibody (#AAR-023-V) is directly conjugated to mFluor Violet 450 fluorophore. This conjugated antibody has been developed to be used in immunofluorescent applications such as direct flow cytometry and live cell imaging. mFluor Violet 450 dye has a maximum absorption of 405 nm and maximum emission of 445 nm. These spectral characteristics make it an excellent replacement for Pacific Blue or Brilliant Violet 421 dyes. For flow cytometry applications, the labeled antibody can be detected using the 405 nm laser lane and a filter set of 450/50.
Formulation	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Host	Rabbit
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	15 ul or 50 ul double distilled water (DDW), depending on the sample size.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Beta-1 adrenoceptor, Beta-1 adrenoreceptor, ADRB1, ADRB1R, B1AR
UNSPSC Code	41116161
Note	Homology: Rat, Mouse, human - 14/15 amino acid residues identical. Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: RIC-001-APC Negative control name : Rabbit IgG Isotype Control-mFluor Violet 450 Standard quality control of each lot: Western blot analysis (unlabeled antibody, #AAR-023), and direct flow cytometry (labeled antibody).

Accession Number	P18090
Gene Id	24925
Target	Beta-1 adrenoceptor, Beta-1 adrenoreceptor, ADRB1, ADRB1R, B1AR
Sequence	(C)RAESDEARR(S)YNDP, corresponding to amino acid residues 200-214 of rat ADRB1

Conjugates	mFluor Violet 450. Maximum absorption 405 nm and maximum emission 445 nm. These spectral characteristics make it an excellent replacement for Pacific Blue or Brilliant Violet 421 dyes. For flow cytometry applications, the labeled antibody can be detected using the 405 nm laser lane and a filter set of 450/50.

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Preservative	1% BSA, 0.05% NaN3
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Applications	FC, LCI

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300042-1	AAR-023-V_15 mcl	15 mcl	$597		Add to Cart
BHA21300042-2	AAR-023-V_50 mcl	50 mcl	$797		Add to Cart
BHA21300042-3	AAR-023-V_50 mcl	2x50 mcl	$1397		Add to Cart
BHA21300042-4	AAR-023-V_50 mcl	5x50 mcl	$2743		Add to Cart
BHA21300042-5	AAR-023-V_50 mcl	10x50 mcl	$3764		Add to Cart

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