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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Beta Arrestin 2/ARRB2 Antibody Picoband®

SKU : BHA21007108

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Mfr.No.	PA1845, PA1845-10ug, PA1845-Biotin, PA1845-Cy3, PA1845-Dylight488, PA1845-Dylight550, PA1845-Dylight594, PA1845-FITC, PA1845-HRP, PA1845-APC, PA1845-PE, PA1845-iFluor647, PA1845-carrier-free
Alternative Names	Beta-arrestin-2
Background	ARRB2 (arrestin beta-2), also known as Beta-arrestin-2, BARR2, ARB2, DKFZp686L0365, arrestin 3, is an intracellularprotein that in humans is encoded by the ARRB2 gene. Members of arrestin/beta-arrestin protein family are though to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals, as well as having signalling roles in their own right. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Beta-arrestins were originally discovered in the context of heterotrimeric G protein-coupled receptor desensitization, but they also function in intealization and signaling of these receptors.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Beta Arrestin 2/ARRB2 Antibody catalog # PA1845. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and s
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Beta Arrestin 2, different from the related rat and mouse sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	46 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Beta-arrestin-2;Arrestin beta-2;ARRB2;ARB2, ARR2;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P32121
Gene Name	ARRB2
Sequence	Belongs to the arrestin family.
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Alloway, P. G., Howard, L., Dolph, P. J. The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration. Neuron 28: 129-138, 2000.<br /><br />2. Beaulieu, J.-M., Marion, S., Rodriguiz, R. M., Medvedev, I. O., Sotnikova, T. D., Ghisi, V., Wetsel, W. C., Lefkowitz, R. J., Gainetdinov, R. R., Caron, M. G. A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell 132: 125-136, 2008.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007108-1	PA1845	-	100 ug	$370		Add to Cart
BHA21007108-2	PA1845-10ug	Sample	10 ug	$99		Add to Cart
BHA21007108-3	PA1845-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007108-4	PA1845-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007108-5	PA1845-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007108-6	PA1845-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007108-7	PA1845-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007108-8	PA1845-FITC	FITC	100 ug	$570		Add to Cart
BHA21007108-9	PA1845-HRP	HRP	100 ug	$570		Add to Cart
BHA21007108-10	PA1845-APC	APC	100 ug	$670		Add to Cart
BHA21007108-11	PA1845-PE	PE	100 ug	$670		Add to Cart
BHA21007108-12	PA1845-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007108-13	PA1845-carrier-free	carrier-free	100 ug	$370		Add to Cart

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