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Home / Primary Antibodies / Polyclonal Antibodies

Anti-beta Arrestin 1/ARRB1 Antibody Picoband®

SKU : BHA21007355

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Mfr.No.	PA2155, PA2155-10ug, PA2155-Biotin, PA2155-Cy3, PA2155-Dylight488, PA2155-Dylight550, PA2155-Dylight594, PA2155-FITC, PA2155-HRP, PA2155-APC, PA2155-PE, PA2155-iFluor647, PA2155-carrier-free
Alternative Names	Beta-arrestin-1
Background	Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene. Members of arrestin/beta-arrestin protein family are though to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. By fluorescence in situ hybridization, this gene is mapped to 11q13.4. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-beta Arrestin 1/ARRB1 Antibody catalog # PA2155. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and s
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human beta Arrestin 1, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	18 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Beta-arrestin-1;Arrestin beta-1;ARRB1;ARR1;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P49407
Gene Name	ARRB1
Sequence	Belongs to the arrestin family.
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Buchanan, F. G., Gorden, D. L., Matta, P., Shi, Q., Matrisian, L. M., DuBois, R. N. Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc. Nat. Acad. Sci. 103: 1492-1497, 2006.<br /><br />2. Nelson, C. D., Perry, S. J., Regier, D. S., Prescott, S. M., Topham, M. K., Lefkowitz, R. J.Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science 315: 663-666, 2007. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007355-1	PA2155	-	100 ug	$370		Add to Cart
BHA21007355-2	PA2155-10ug	Sample	10 ug	$99		Add to Cart
BHA21007355-3	PA2155-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007355-4	PA2155-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007355-5	PA2155-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007355-6	PA2155-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007355-7	PA2155-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007355-8	PA2155-FITC	FITC	100 ug	$570		Add to Cart
BHA21007355-9	PA2155-HRP	HRP	100 ug	$570		Add to Cart
BHA21007355-10	PA2155-APC	APC	100 ug	$670		Add to Cart
BHA21007355-11	PA2155-PE	PE	100 ug	$670		Add to Cart
BHA21007355-12	PA2155-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007355-13	PA2155-carrier-free	carrier-free	100 ug	$370		Add to Cart

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