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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Bestrophin-2 (extracellular) Antibody

SKU : BHA21300055

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Alomone Labs

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Mfr.No.	ABC-002, ABC-002-CF_0.2 ml, ABC-002_0.2 ml, ABC-002_25 mcl, ABC-002_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Mouse
Background	Mammalian Cl- channels can be broadly classified into four different families: voltage-dependent Cl- channels (CLCs), the cystic fibrosis transmembrane conductance regulator (CFTR), ligand-gated Cl- channels (gamma-aminobutyric acid (GABA)) and glycine channels) and Ca2+-activated Cl- channels (Bestrophin and Anoctamin channels).Bestrophins were first found by genetic linkage of human-Bestrophin-1 (hBest1) to a juvenile form of macular degeneration called Best vitelliform macular dystrophy1,2. To date Bestrophin 1-4 have been identified, although Bestrophin-3 and Bestrophin-4 have been observed only at the RNA level3. In addition, splice variants of some of these Ca2+-activated Cl- channels (CaCCs) have also been detected2,4,5. CaCCs are known to be involved in the regulation of olfaction, taste, phototransduction, and excitability in the nervous system. However, the molecular identity and functional role of CaCC in the brain have not been well established6. Bestrophin-2 is prominently expressed in colon and testes. Recently, Bestrophin-2 has also been found to be expressed in olfactory sensory neurons (OSNs)7.Two different topologies for Bestrophin-1 have been proposed. The first structure proposes that six hydrophobic domains span the membrane8, while the second suggests that there are only four membrane-spanning domains9. The same structural controversy applies to Bestrophin-2. Bestrophin-1 and Bestrophin-2 (as well as Bestrophin-4 by heterologous expression) are activated by intracellular Ca2+ 10-12. Ca2+-dependent activation of Bestrophin-2 was also demonstrated in Xenopus13.
Clonality	Polyclonal
Description	Alomone Labs is pleased to offer a highly specific antibody directed against an epitope located at the 3rd extracellular loop of mouse Bestrophin-2. Anti-Bestrophin-2 (extracellular) Antibody (#ABC-002) can be used in western blot and immunohistochemical applications, and has been designed to recognize bestrophin-2 channel from mouse, rat and human samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	3rd extracellular loop
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	BEST2, Vitelliform macular dystrophy 2-like protein 1, VMD2L1
UNSPSC Code	41116161
Note	Homology: Rat - identical; human - 11/12 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-BC002 Specifictiy: BEST2 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	Q8BGM5
Gene Id	212989
Target	BEST2, Vitelliform macular dystrophy 2-like protein 1, VMD2L1
Sequence	(C)DPAQGYKDHTLD, corresponding to amino acid residues 259-270 of mouse Bestrophin-2

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IHC, WB
Dilution	Immunohistochemistry paraffin embedded sections ihc: 1:100 Western blot wb: 1:200

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300055-1	ABC-002-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21300055-2	ABC-002_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300055-3	ABC-002_25 mcl	25 mcl	$497		Add to Cart
BHA21300055-4	ABC-002_50 mcl	50 mcl	$697		Add to Cart

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