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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Beclin 1/BECN1 Antibody Picoband®

SKU : BHA21007109

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Mfr.No.	PA1847, PA1847-10ug, PA1847-Biotin, PA1847-Cy3, PA1847-Dylight488, PA1847-Dylight550, PA1847-Dylight594, PA1847-FITC, PA1847-HRP, PA1847-APC, PA1847-PE, PA1847-iFluor647, PA1847-carrier-free
Alternative Names	Beclin-1
Background	Bellini-1 (beclin 1, autophagy related) is a protein that in humans is encoded by the BECN1 gene, also known as BECN1, ATG6, VPS30, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, autophagy-related gene (Atg) 6. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. Human beclin encodes a novel 450-amino acid protein containing a coiled-coil region, within which it has limited homology to myosin-like proteins. Northe blot analysis of mouse and adult human tissues revealed widespread beclin expression. A 2.2-kb transcript was present at highest levels in human skeletal muscle and at detectable levels in all tissues examined. In some tissues, additional 1.7- and 1.4-kb transcripts were observed, suggesting the presence of alteatively spliced transcripts. Immunoperoxidase staining of human hippocampus and frontal cortex sections revealed beclin immunoreactivity in many neurons throughout these regions, as well as in some glial cells. Beclin protects against infection by a neurovirulent strain of Sindbis virus that is known to overcome the protective effects of Bcl2. Liang et al. showed that beclin reduced Sindbis virus replication in mouse brain and reduced Sindbis virus-induced cell death in mouse brain.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Beclin 1/BECN1 Antibody catalog # PA1847. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Beclin 1, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	46 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Beclin-1;Coiled-coil myosin-like BCL2-interacting protein;Protein GT197;BECN1;GT197;
Tissue Specificity	Ubiquitous.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q14457
Gene Name	BECN1
Subcellular Location	Cytoplasm . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Liang, X. H., Kleeman, L. K., Jiang, H. H., Gordon, G., Goldman, J. E., Berry, G., Herman, B., Levine, B.Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72: 8586-8596, 1998.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007109-1	PA1847	-	100 ug	$370		Add to Cart
BHA21007109-2	PA1847-10ug	Sample	10 ug	$99		Add to Cart
BHA21007109-3	PA1847-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007109-4	PA1847-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007109-5	PA1847-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007109-6	PA1847-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007109-7	PA1847-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007109-8	PA1847-FITC	FITC	100 ug	$570		Add to Cart
BHA21007109-9	PA1847-HRP	HRP	100 ug	$570		Add to Cart
BHA21007109-10	PA1847-APC	APC	100 ug	$670		Add to Cart
BHA21007109-11	PA1847-PE	PE	100 ug	$670		Add to Cart
BHA21007109-12	PA1847-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007109-13	PA1847-carrier-free	carrier-free	100 ug	$370		Add to Cart

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