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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Beclin 1/BECN1 Antibody Picoband®

SKU : BHA21007530

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Mfr.No.	PB9076, PB9076-10ug, PB9076-Biotin, PB9076-Cy3, PB9076-Dylight488, PB9076-Dylight550, PB9076-Dylight594, PB9076-FITC, PB9076-HRP, PB9076-APC, PB9076-PE, PB9076-iFluor647, PB9076-carrier-free
Alternative Names	Beclin-1
Background	Beclin-1, also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. This gene participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagywhich in tu results in increased neuronal cell death. It has been found that beclin-1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30, and in human MCF7 breast carcinoma cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Beclin 1/BECN1 Antibody Picoband® catalog # PB9076. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC
Host	Rabbit
Immunogen Region	E.coli-derived human Beclin 1 recombinant protein (Position: M1-S354). Human Beclin 1 shares 97% amino acid (aa) sequence identity with both mouse and rat Beclin 1.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Beclin-1;Coiled-coil myosin-like BCL2-interacting protein;Protein GT197;BECN1;GT197;
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q14457
Gene Id	8678
Gene Name	BECN1
Sequence	Belongs to the lipoxygenase family.
Subcellular Location	Cytoplasm . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.1-0.5 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Liang, X. H., Kleeman, L. K., Jiang, H. H., Gordon, G., Goldman, J. E., Berry, G., Herman, B., Levine, B.Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72: 8586-8596, 1998. 2. Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, Dean B, Levine J, Agam G, Gozes I (December 2013). "Autophagy has a key role in the pathophysiology of schizophrenia". Mol. Psychiatry.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007530-1	PB9076	-	100 ug	$370		Add to Cart
BHA21007530-2	PB9076-10ug	Sample	10 ug	$99		Add to Cart
BHA21007530-3	PB9076-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007530-4	PB9076-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007530-5	PB9076-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007530-6	PB9076-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007530-7	PB9076-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007530-8	PB9076-FITC	FITC	100 ug	$570		Add to Cart
BHA21007530-9	PB9076-HRP	HRP	100 ug	$570		Add to Cart
BHA21007530-10	PB9076-APC	APC	100 ug	$670		Add to Cart
BHA21007530-11	PB9076-PE	PE	100 ug	$670		Add to Cart
BHA21007530-12	PB9076-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007530-13	PB9076-carrier-free	carrier-free	100 ug	$370		Add to Cart

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