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Home / Primary Antibodies / Polyclonal Antibodies

Anti-BCRP/ABCG2 Antibody Picoband®

SKU : BHA21007126

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Mfr.No.	PA1869, PA1869-10ug, PA1869-Biotin, PA1869-Cy3, PA1869-Dylight488, PA1869-Dylight550, PA1869-Dylight594, PA1869-FITC, PA1869-HRP, PA1869-APC, PA1869-PE, PA1869-iFluor647, PA1869-carrier-free
Alternative Names	ATP-binding cassette sub-family G member 2
Background	ABCG2 (Atp-binding cassette, subfamily g, member 2) also known as ABCP, BCRP or MRX, is a protein that in humans is encoded by the ABCG2 gene. The ABCG2 gene encodes a membrane transporter belonging to the ATP-binding cassette (ABC) superfamily of membrane transporters, which are involved in the trafficking of biologic molecules across cell membranes. The ABCG2 protein is also a high capacity transporter for uric acid excretion in the kidney, liver, and gut. The ABCG2 gene is mapped on 4q22.1. In vitro assays of isolated membrane preparations revealed a high-capacity, vanadate-sensitive ATPase activity associated with ABCG2 expression that was stimulated by compounds known to be transported by this protein. Ozvegy et al. (2001) concluded that ABCG2 is likely functioning as a homodimer or homooligomer in this expression system since it is unlikely that putative Sf9 transport partners would be overexpressed at similarly high levels.Abcg2 transports pheophorbide-a, which occurs in various plant-derived foods and food supplements and is highly efficient in limiting its uptake from ingested food. ABCG2 is a major factor in the concentrative transfer of drugs, carcinogens, and dietary toxins to the milk of mice, cows, and humans.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-BCRP/ABCG2 Antibody catalog # PA1869. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellula
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human BCRP/ABCG2.
Isotype	Rabbit IgG
Molecular Weight	75 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	ATP-binding cassette sub-family G member 2;Breast cancer resistance protein;CDw338;Mitoxantrone resistance-associated protein;Placenta-specific ATP-binding cassette transporter;Urate exporter;CD338;ABCG2;ABCP, BCRP, BCRP1, MXR;
Tissue Specificity	Highly expressed in placenta. Low expression in small intestine, liver and colon. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9UNQ0
Gene Name	ABCG2
Sequence	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Jonker, J. W., Merino, G., Musters, S., van Herwaarden, A. E., Bolscher, E., Wagenaar, E., Mesman, E., Dale, T. C., Schinkel, A. H. The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nature Med. 11: 127-129, 2005.<br /><br />2. Matsuo, H., Takada, T., Ichida, K., Nakamura, T., Nakayama, A., Ikebuchi, Y., Ito, K., Kusanagi, Y., Chiba, T., Tadokoro, S., Takada, Y., Oikawa, Y., and 22 others. Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.Sci. Transl. Med. 1: 5ra11, 2009. <br /><br />3. Ozvegy, C., Litman, T., Szakacs, G., Nagy, Z., Bates, S., Varadi, A., Sarkadi, B. Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.Biochem. Biophys. Res. Commun. 285: 111-117, 2001.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007126-1	PA1869	-	100 ug	$370		Add to Cart
BHA21007126-2	PA1869-10ug	Sample	10 ug	$99		Add to Cart
BHA21007126-3	PA1869-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007126-4	PA1869-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007126-5	PA1869-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007126-6	PA1869-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007126-7	PA1869-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007126-8	PA1869-FITC	FITC	100 ug	$570		Add to Cart
BHA21007126-9	PA1869-HRP	HRP	100 ug	$570		Add to Cart
BHA21007126-10	PA1869-APC	APC	100 ug	$670		Add to Cart
BHA21007126-11	PA1869-PE	PE	100 ug	$670		Add to Cart
BHA21007126-12	PA1869-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007126-13	PA1869-carrier-free	carrier-free	100 ug	$370		Add to Cart

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