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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Aurora B/AURKB Antibody Picoband®

SKU : BHA21007074

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Mfr.No.	PA1806, PA1806-10ug, PA1806-Biotin, PA1806-Cy3, PA1806-Dylight488, PA1806-Dylight550, PA1806-Dylight594, PA1806-FITC, PA1806-HRP, PA1806-APC, PA1806-PE, PA1806-iFluor647, PA1806-carrier-free
Alternative Names	Aurora kinase B
Background	AURKB (aurora kinase B) also called Aik2, AIM-1, ARK2, AurB, STK12, IPL1, PPP1R48 or STK5, localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. Cell cycle and Northe blot analyses showed that STK12 is expressed in the S phase and persistently thereafter. Weste blot analysis indicated that STK12 is localized in the midbodies during anaphase. Northe blot analysis detected strong expression of a 1.5-kb STK12 transcript in thymus, with weaker expression in small intestine, testis, colon, spleen, and brain. The AURKB gene is mapped on 17p13.1. Examination of the role of both kinases in the phosphorylation of CENPA revealed that the reaction is mediated sequentially by AURKA and AURKB in early mitosis. EB1 overexpression enhanced AURKB kinase activity, and knockdown of EB1 with small interfering RNA impaired AURKB activity. EB1 protected AURKB from dephosphorylation/inactivation by protein phosphatase-2A by blocking binding of PP2A to AURKB.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Aurora B/AURKB Antibody catalog # PA1806. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of mouse Aurora B, different from the related rat sequence by two anino acids.
Isotype	Rabbit IgG
Molecular Weight	38 kDa
Reactivity	Rat, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Aurora kinase B;2.7.11.1;Aurora 1;Aurora- and IPL1-like midbody-associated protein 1;Aurora/IPL1-related kinase 2;ARK-2;Aurora-related kinase 2;STK-1;Serine/threonine-protein kinase 12;Serine/threonine-protein kinase 5;Serine/threonine-protein kinase aurora-B;Aurkb;Aik2, Aim1, Airk2, Ark2, Stk1, Stk12, Stk5;
Tissue Specificity	Expressed in testis, intestine and spleen. All of them are tissues that contain a large number of proliferating cells. Expressed during S phase, in a cell-cycle-dependent fashion.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O70126
Gene Name	AURKB
Sequence	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Subcellular Location	Nucleus . Chromosome . Chromosome, centromere . Cytoplasm, cytoskeleton, spindle . Midbody . Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body (By similarity). Proper localization of the active, Thr-237-phosphorylated form during metaphase may be dependent upon interaction with SPDYC. Colocalized with SIRT2 during cytokinesis with the midbody (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Rat, Mouse<br>

Reference	1. Andrews, P. D., Ovechkina, Y., Morrice, N., Wagenbach, M., Duncan, K., Wordeman, L., Swedlow, J. R. Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6: 253-268, 2004.<br /><br />2. Katayama, H., Ota, T., Morita, K., Terada, Y., Suzuki, F., Katoh, O., Tatsuka, M. Human AIM-1: cDNA cloning and reduced expression during endomitosis in megakaryocyte-lineage cells. Gene 224: 1-7, 1998.<br /><br />3. Ramadan, K., Bruderer, R., Spiga, F. M., Popp, O., Baur, T., Gotta, M., Meyer, H. H. Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature 450: 1258-1262, 2007. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007074-1	PA1806	-	100 ug	$370		Add to Cart
BHA21007074-2	PA1806-10ug	Sample	10 ug	$99		Add to Cart
BHA21007074-3	PA1806-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007074-4	PA1806-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007074-5	PA1806-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007074-6	PA1806-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007074-7	PA1806-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007074-8	PA1806-FITC	FITC	100 ug	$570		Add to Cart
BHA21007074-9	PA1806-HRP	HRP	100 ug	$570		Add to Cart
BHA21007074-10	PA1806-APC	APC	100 ug	$670		Add to Cart
BHA21007074-11	PA1806-PE	PE	100 ug	$670		Add to Cart
BHA21007074-12	PA1806-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007074-13	PA1806-carrier-free	carrier-free	100 ug	$370		Add to Cart

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