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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ATR Antibody

SKU : BHA21003846

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Mfr.No.	A00262-2, A00262-2-10ug, A00262-2-Biotin, A00262-2-Cy3, A00262-2-Dylight488, A00262-2-Dylight550, A00262-2-Dylight594, A00262-2-FITC, A00262-2-HRP, A00262-2-APC, A00262-2-PE, A00262-2-iFluor647, A00262-2-carrier-free
Alternative Names	aryl hydrocarbon receptor nuclear translocator like
Background	Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ATR Antibody Picoband® catalog # A00262-2. Tested in ELISA, IF, ICC applications. This antibody reacts with Human.
Function	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an inteal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expres
Host	Rabbit
Immunogen Region	E.coli-derived human ATR recombinant protein (Position: E24-D1324).
Isotype	Rabbit IgG
Molecular Weight	301 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3; ARNTL; BHLHE5, BMAL1, MOP3, PASD3
Tissue Specificity	Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q13535
Gene Id	545
Gene Name	ATR
Subcellular Location	Nucleus . Cytoplasm . Nucleus, PML body . Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, IF, ICC
Description	Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Alderton, G. K., Joenje, H., Varon, R., Borglum, A. D., Jeggo, P. A., O'Driscoll, M. Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Hum. Molec. Genet. 13: 3127-3138, 2004. 2. Bao, S., Tibbetts, R. S., Brumbaugh, K. M., Fang, Y., Richardson, D. A., Ali, A., Chen, S. M., Abraham, R. T., Wang, X.-F. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature 411: 969-974, 2001. 3. Brown, E. J., Baltimore, D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14: 397-402, 2000.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003846-1	A00262-2	-	100 ug	$370		Add to Cart
BHA21003846-2	A00262-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003846-3	A00262-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003846-4	A00262-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003846-5	A00262-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003846-6	A00262-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003846-7	A00262-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003846-8	A00262-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003846-9	A00262-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003846-10	A00262-2-APC	APC	100 ug	$670		Add to Cart
BHA21003846-11	A00262-2-PE	PE	100 ug	$670		Add to Cart
BHA21003846-12	A00262-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003846-13	A00262-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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