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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Aquaporin 4/AQP4 Antibody Picoband®

SKU : BHA21007176

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Mfr.No.	PA1937, PA1937-10ug, PA1937-Biotin, PA1937-Cy3, PA1937-Dylight488, PA1937-Dylight550, PA1937-Dylight594, PA1937-FITC, PA1937-HRP, PA1937-APC, PA1937-PE, PA1937-iFluor647, PA1937-carrier-free
Alternative Names	Aquaporin-4
Background	AQP4 (Aquaporin 4), also known as MERCURIAL-INSENSITIVE WATER CHANNEL; MIWC, is protein which in humans is encoded by the AQP4 gene. The aquaporins are a family of water-selective membrane channels found in animals, plants, and microorganisms. AQP4 is the predominant water channel in the brain and has an important role in brain water homeostasis. By fluorescence in situ hybridization, Lu et al. (1996) determined that the AQP4 gene maps to 18q11.2-q12.1. By interspecific backcross analysis, Turtzo et al. (1997) mapped the mouse Aqp4 gene to the proximal region of chromosome 18. Analyzing the expression of AQP4 in mammalian skeletal muscle, Frigeri et al. (1998) found that, in immunohistochemical experiments, affinity-purified AQP4 antibodies stained selectively the sarcolemma of fast-twitch fibers. Immunocytochemistry revealed strong AQP4 water channel expression in Muller cells in mouse retina and in fibrous astrocytes in optic nerve.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Aquaporin 4/AQP4 Antibody catalog # PA1937. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 4, different from the related rat and mouse sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	24 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Aquaporin-4;AQP-4;Mercurial-insensitive water channel;MIWC;WCH4;AQP4;
Tissue Specificity	Brain - muscle >> heart, kidney, lung, and trachea.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P55087
Gene Name	AQP4
Sequence	Belongs to the MIP/aquaporin (TC 1.A.8) family.
Subcellular Location	Membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Mouse, Rat, By Heat<br>

Reference	1. Frigeri, A., Nicchia, G. P., Verbavatz, J. M., Valenti, G., Svelto, M. Expression of aquaporin-4 in fast-twitch fibers of mammalian skeletal muscle. J. Clin. Invest. 102: 695-703, 1998.<br /><br />2. Lu, M., Lee, M. D., Smith, B. L., Jung, J. S., Agre, P., Verdijk, M. A. J., Merkx, G., Rijss, J. P. L., Deen, P. M. T. The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain. Proc. Nat. Acad. Sci. 93: 10908-10912, 1996.<br /><br />3. Turtzo, L. C., Lee, M. D., Lu, M., Smith, B. L., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Agre, P. Cloning and chromosomal localization of mouse aquaporin 4: exclusion of a candidate mutant phenotype, ataxia. Genomics 41: 267-270, 1997. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007176-1	PA1937	-	100 ug	$370		Add to Cart
BHA21007176-2	PA1937-10ug	Sample	10 ug	$99		Add to Cart
BHA21007176-3	PA1937-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007176-4	PA1937-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007176-5	PA1937-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007176-6	PA1937-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007176-7	PA1937-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007176-8	PA1937-FITC	FITC	100 ug	$570		Add to Cart
BHA21007176-9	PA1937-HRP	HRP	100 ug	$570		Add to Cart
BHA21007176-10	PA1937-APC	APC	100 ug	$670		Add to Cart
BHA21007176-11	PA1937-PE	PE	100 ug	$670		Add to Cart
BHA21007176-12	PA1937-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007176-13	PA1937-carrier-free	carrier-free	100 ug	$370		Add to Cart

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