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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Apoptosis repressor with CARD/NOL3 Antibody Picoband®

SKU : BHA21007063

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Mfr.No.	PA1793, PA1793-10ug, PA1793-Biotin, PA1793-Cy3, PA1793-Dylight488, PA1793-Dylight550, PA1793-Dylight594, PA1793-FITC, PA1793-HRP, PA1793-APC, PA1793-PE, PA1793-iFluor647, PA1793-carrier-free
Alternative Names	Nucleolar protein 3
Background	NOL3 (Nucleolar protein 3), also known as ARC, NOP30, CARD2 and MYP, is a protein that in humans is encoded by the NOL3 gene. NOL3 has been shown to interact with SFRS9 and Caspase 8. By genomic sequence analysis, Stoss et al. (1999) determined that the NOL3 gene, which encodes NOP30 and MYP and which they called NOP, is composed of 4 exons. The alteative 5-prime splice site that generates the 2 isoforms is located in exon 2. It is reported that expression of the ARC cDNA encoding the smaller transcript inhibited apoptosis in a dose-dependent manner when coexpressed with CASP8 but not when coexpressed with CASP9. ARC also inhibited apoptosis induced by stimulation of CD95/FAS, tumor necrosis factor receptor-1, and TRAMP/death receptor-3. Enzymatic analysis showed that ARC inhibits the enzymatic activity of CASP8. Immunoprecipitation and immunoblot analysis indicated that ARC interacts with CASP2 and CASP8 through its N-terminal death effector domain but does not interact with CASP1, CASP3, or CASP9.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Apoptosis repressor with CARD/NOL3 Antibody catalog # PA1793. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Isoform 1: May be involved in RNA splicing. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Apoptosis repressor with CARD, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	27 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Nucleolar protein 3 ;Apoptosis repressor with CARD ;Muscle-enriched cytoplasmic protein ;Myp ;Nucleolar protein of 30 kDa ;Nop30 ;NOL3 ;ARC , NOP ;
Tissue Specificity	Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver, kidney and pancreas.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg Thimerosal, 0.01mg NaN3.

Uniprot	O60936
Gene Name	NOL3
Sequence	Contains 1 CARD domain.
Subcellular Location	Isoform 1: Nucleus, nucleolus . The SR-rich C-terminus mediates nuclear localization. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat<br>

Reference	1. Abmayr, S., Crawford, R. W., Chamberlain, J. S.Characterization of ARC, apoptosis repressor interacting with CARD, in normal and dystrophin-deficient skeletal muscle.Hum. Molec. Genet. 13: 213-221, 2004.<br /><br />2. Koseki, T., Inohara, N., Chen, S., Nunez, G.ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.Proc. Nat. Acad. Sci. 95: 5156-5160, 1998.<br /><br />3. Stoss, O., Schwaiger, F.-W., Cooper, T. A., Stamm, S.Alteative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c.J. Biol. Chem. 274: 10951-10962, 1999.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007063-1	PA1793	-	100 ug	$370		Add to Cart
BHA21007063-2	PA1793-10ug	Sample	10 ug	$99		Add to Cart
BHA21007063-3	PA1793-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007063-4	PA1793-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007063-5	PA1793-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007063-6	PA1793-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007063-7	PA1793-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007063-8	PA1793-FITC	FITC	100 ug	$570		Add to Cart
BHA21007063-9	PA1793-HRP	HRP	100 ug	$570		Add to Cart
BHA21007063-10	PA1793-APC	APC	100 ug	$670		Add to Cart
BHA21007063-11	PA1793-PE	PE	100 ug	$670		Add to Cart
BHA21007063-12	PA1793-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007063-13	PA1793-carrier-free	carrier-free	100 ug	$370		Add to Cart

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