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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Apoptosis inhibitor 5/API5 Antibody Picoband®

SKU : BHA21006610

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Mfr.No.	PA1009, PA1009-10ug, PA1009-Biotin, PA1009-Cy3, PA1009-Dylight488, PA1009-Dylight550, PA1009-Dylight594, PA1009-FITC, PA1009-HRP, PA1009-APC, PA1009-PE, PA1009-iFluor647, PA1009-carrier-free
Alternative Names	Apoptosis inhibitor 5
Background	Many growth factors and cytokines act as cellular survival factors by preventing programmed cell death (apoptosis). Apoptosis inhibitor 5 (API5) is an antiapoptotic factor which may have a role in protein assembly. The API5 gene to chromosome 11p12 based on an alignment of the API5 sequence with the genomic sequence It is a critical determinant of E2F1-induced apoptosis, acting downstream of E2F to suppress E2F-dependent apoptosis without generally blocking E2F-dependent transcription.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Apoptosis inhibitor 5/API5 Antibody catalog # PA1009. Tested in IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its de
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Apoptosis inhibitor 5, different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	59 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Apoptosis inhibitor 5;API-5;Antiapoptosis clone 11 protein;AAC-11;Cell migration-inducing gene 8 protein;Fibroblast growth factor 2-interacting factor;FIF;Protein XAGL;API5;MIG8;
Tissue Specificity	Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9BZZ5
Gene Name	API5
Sequence	Belongs to the API5 family.
Subcellular Location	Nucleus . Cytoplasm . Mainly nuclear. Can also be cytoplasmic.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Rat, Human, Mouse<br> Immunocytochemistry , 0.5-1ug/ml, Human, Mouse<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br>

Reference	1. Hartz, P. A.Personal Communication.Baltimore, Md. 12/12/2005.<br /><br />2. Tewari, M.; Yu, M.; Ross, B.; Dean, C.; Giordano, A.; Rubin, R. : AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res. 57: 4063-4069, 1997.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006610-1	PA1009	-	100 ug	$370		Add to Cart
BHA21006610-2	PA1009-10ug	Sample	10 ug	$99		Add to Cart
BHA21006610-3	PA1009-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006610-4	PA1009-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006610-5	PA1009-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006610-6	PA1009-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006610-7	PA1009-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006610-8	PA1009-FITC	FITC	100 ug	$570		Add to Cart
BHA21006610-9	PA1009-HRP	HRP	100 ug	$570		Add to Cart
BHA21006610-10	PA1009-APC	APC	100 ug	$670		Add to Cart
BHA21006610-11	PA1009-PE	PE	100 ug	$670		Add to Cart
BHA21006610-12	PA1009-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006610-13	PA1009-carrier-free	carrier-free	100 ug	$370		Add to Cart

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