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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Apolipoprotein J/CLU Antibody Picoband®

SKU : BHA21000472

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Mfr.No.	PB9575, PB9575-10ug, PB9575-Biotin, PB9575-Cy3, PB9575-Dylight488, PB9575-Dylight550, PB9575-Dylight594, PB9575-FITC, PB9575-HRP, PB9575-APC, PB9575-PE, PB9575-iFluor647, PB9575-carrier-free
Alternative Names	Clusterin
Background	Clusterin (apolipoprotein J) is a 75 - 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is encoded by the CLU gene. This protein has several synonyms: dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI). Clusterin was mapped to mouse chromosome 14. Clusterin is a ubiquitously expressed molecule thought to influence a variety of processes including cell death. In the brain, it accumulates in dying neurons following seizures and hypoxic-ischemic (H-I) injury. clusterin may be a new therapeutic target to modulate non-caspase-dependent neuronal death following acute brain injury.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Apolipoprotein J/CLU Antibody Picoband® catalog # PB9575. Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-pron
Host	Rabbit
Immunogen Region	E. coli-derived human Apolipoprotein J recombinant protein (Position: S228-E449). Human Apolipoprotein J shares 76.1 % and 75.2 % amino acid (aa) sequence identity with mouse and rat Apolipoprotein J, respectively.
Isotype	Rabbit IgG
Molecular Weight	82 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Clusterin;Aging-associated gene 4 protein;Apolipoprotein J;Apo-J;Complement cytolysis inhibitor;CLI;Complement-associated protein SP-40,40;Ku70-binding protein 1;NA1/NA2;Testosterone-repressed prostate message 2;TRPM-2;Clusterin beta chain;ApoJalpha;Complement cytolysis inhibitor a chain;Clusterin alpha chain;ApoJbeta;Complement cytolysis inhibitor b chain;CLU;APOJ, CLI, KUB1;AAG4;
Tissue Specificity	Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P10909
Gene Id	1191
Gene Name	CLU
Sequence	Belongs to the clusterin family.
Subcellular Location	Isoform 1: Secreted. Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	ELISA, 0.1-0.5ug/ml, - Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. "Entrez Gene: clusterin". 2. Birkenmeier, E. H., Letts, V. A., Frankel, W. N., Magenheimer, B. S., Calvet, J. P. Sulfated glycoprotein-2 (Sgp-2) maps to mouse chromosome 14. Mammalian Genome 4: 131-132, 1993. 3. Han, B. H., DeMattos, R. B., Dugan, L. L., Kim-Han, J. S., Brendza, R. P., Fryer, J. D., Kierson, M., Cirrito, J., Quick, K., Harmony, J. A. K., Aronow, B. J., Holtzman, D. M. Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Nature Med. 7: 338-343, 2001. 4. Jones SE, Jomary C (May 2002). "Clusterin". Int. J. Biochem. Cell Biol. 34 (5): 427431.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000472-1	PB9575	100 ug	-	$370		Add to Cart
BHA21000472-2	PB9575-10ug	10 ug	Sample	$99		Add to Cart
BHA21000472-3	PB9575-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000472-4	PB9575-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000472-5	PB9575-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000472-6	PB9575-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000472-7	PB9575-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000472-8	PB9575-FITC	100 ug	FITC	$570		Add to Cart
BHA21000472-9	PB9575-HRP	100 ug	HRP	$570		Add to Cart
BHA21000472-10	PB9575-APC	100 ug	APC	$670		Add to Cart
BHA21000472-11	PB9575-PE	100 ug	PE	$670		Add to Cart
BHA21000472-12	PB9575-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000472-13	PB9575-carrier-free	100 ug	carrier-free	$370		Add to Cart

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