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Home / Primary Antibodies / Polyclonal Antibodies

Anti-APE1/APEX1 Antibody Picoband®

SKU : BHA21006839

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Mfr.No.	PA1494, PA1494-10ug, PA1494-Biotin, PA1494-Cy3, PA1494-Dylight488, PA1494-Dylight550, PA1494-Dylight594, PA1494-FITC, PA1494-HRP, PA1494-APC, PA1494-PE, PA1494-iFluor647, PA1494-carrier-free
Alternative Names	DNA-(apurinic or apyrimidinic site) lyase
Background	APEX1, also called apurinic endonuclease (APE), is a DNA repair enzyme having apurinic/apyrimidinic (AP) endonuclease, 3-prime,5-prime-exonuclease, DNA 3-prime repair diesterase, and DNA 3-prime-phosphatase activities. The human APEX1 gene consists of 5 exons spanning 2.64 kb and exists as a single copy in the haploid genome. Using in situ hybridization, the APEX1 gene is mapped to 14q11.2-q12. The predicted APEX1 protein, which contained probable nuclear transport signals, was identified as a member of a family of DNA repair enzymes found in lower organisms. The abundance of the large form of APEX1 was increased in leiomyoma extracts relative to myometrial tissue extracts, and the large form was dominant in cell lines derived from leiomyosarcomas. The exonuclease activity of nuclear APEX1 can remove the anti-HIV nucleoside analogs AZT and D4T from the 3-prime terminus of a nick more efficiently than can cytosolic exonucleases.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-APE1/APEX1 Antibody catalog # PA1494. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonucleas
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human APE1, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	36 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	DNA- (apurinic or apyrimidinic site) lyase;3.1.-.-;4.2.99.18;APEX nuclease;APEN;Apurinic-apyrimidinic endonuclease 1;AP endonuclease 1;APE-1;REF-1;Redox factor-1;DNA- (apurinic or apyrimidinic site) lyase, mitochondrial;APEX1;APE, APE1, APEX, APX, HAP1, REF1;
Tissue Specificity	Released primarily from activated T lymphocytes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P27695
Gene Name	APEX1
Sequence	Belongs to the DNA repair enzymes AP/ExoA family.
Subcellular Location	Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Detected in the cytoplasm of B-cells stimulated to switch (By similarity). Colocalized with SIRT1 in the nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic stress. Together with OGG1 is recruited to nuclear speckles in UVA-irradiated cells. Colocalized with nucleolin and NPM1 in the nucleolus. Its nucleolar localization is cell cycle dependent and requires active rRNA transcription. Colocalized with calreticulin in the endoplasmic reticulum. Translocation from the nucleus to the cytoplasm is stimulated in presence of nitric oxide (NO) and function in a CRM1-dependent manner, possibly as a consequence of demasking a nuclear export signal (amino acid position 64-80). S-nitrosylation at Cys-93 and Cys-310 regulates its nuclear-cytosolic shuttling. Ubiquitinated form is localized predominantly in the cytoplasm. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Akiyama, K., Seki, S., Oshida, T., Yoshida, M. C.Structure, promoter analysis and chromosomal assignment of the human APEX gene.Biochim. Biophys. Acta 1219: 15-25, 1994.<br /><br />2. Chou, K.-M., Cheng, Y.-C.An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3-prime mispaired DNA.Nature 415: 655-659, 2002.<br /><br />3. Robson, C. N., Hochhauser, D., Craig, R., Rack, K., Buckle, V. J., Hickson, I. D.Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q11.2-12.Nucleic Acids Res. 20: 4417-4421, 1992.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006839-1	PA1494	-	100 ug	$370		Add to Cart
BHA21006839-2	PA1494-10ug	Sample	10 ug	$99		Add to Cart
BHA21006839-3	PA1494-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006839-4	PA1494-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006839-5	PA1494-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006839-6	PA1494-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006839-7	PA1494-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006839-8	PA1494-FITC	FITC	100 ug	$570		Add to Cart
BHA21006839-9	PA1494-HRP	HRP	100 ug	$570		Add to Cart
BHA21006839-10	PA1494-APC	APC	100 ug	$670		Add to Cart
BHA21006839-11	PA1494-PE	PE	100 ug	$670		Add to Cart
BHA21006839-12	PA1494-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006839-13	PA1494-carrier-free	carrier-free	100 ug	$370		Add to Cart

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