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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Antithrombin III/SERPINC1 Antibody Picoband®

SKU : BHA21007404

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Mfr.No.	PA2218, PA2218-10ug, PA2218-Biotin, PA2218-Cy3, PA2218-Dylight488, PA2218-Dylight550, PA2218-Dylight594, PA2218-FITC, PA2218-HRP, PA2218-APC, PA2218-PE, PA2218-iFluor647, PA2218-carrier-free
Alternative Names	Antithrombin-III
Background	Serpin peptidase inhibitor, clade C (antithrombin), member 1, also known as Antithrombin III (AT3) is the most important inhibitor of thrombin OMBIN III and other coagulation proteinases. This gene is mapped to 1q25.1. The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Antithrombin III/SERPINC1 Antibody catalog # PA2218. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Antithrombin III, different from the related mouse and rat sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	57 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Antithrombin-III;ATIII;Serpin C1;SERPINC1;AT3;PRO0309;
Tissue Specificity	Found in plasma.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P01008
Gene Name	SERPINC1
Sequence	Belongs to the serpin family.
Subcellular Location	Secreted, extracellular space.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Baud, O., Picard, V., Durand, P., Duchemin, J., Proulle, V., Albenc-Gelas, M., Devictor, D., Dreyfus, M. Intracerebral hemorrhage associated with a novel antithrombin gene mutation in a neonate. J. Pediat. 139: 741-743, 2001.<br /><br />2. Fischer, A. M., Cou, P., Steberg, C., Meriane, F., Dautzenberg, M. D., Chafa, O., Beguin, S., Desnos, M. Antithrombin III Alger: a new homozygous AT III variant. Thromb. Haemost. 55: 218-221, 1986.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007404-1	PA2218	-	100 ug	$370		Add to Cart
BHA21007404-2	PA2218-10ug	Sample	10 ug	$99		Add to Cart
BHA21007404-3	PA2218-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007404-4	PA2218-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007404-5	PA2218-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007404-6	PA2218-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007404-7	PA2218-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007404-8	PA2218-FITC	FITC	100 ug	$570		Add to Cart
BHA21007404-9	PA2218-HRP	HRP	100 ug	$570		Add to Cart
BHA21007404-10	PA2218-APC	APC	100 ug	$670		Add to Cart
BHA21007404-11	PA2218-PE	PE	100 ug	$670		Add to Cart
BHA21007404-12	PA2218-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007404-13	PA2218-carrier-free	carrier-free	100 ug	$370		Add to Cart

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