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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Angiotensin-(1-7) Mas Receptor Antibody

SKU : BHA21300022

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Mfr.No.	AAR-013, AAR-013-CF_0.2 ml, AAR-013_0.2 ml, AAR-013_25 mcl, AAR-013_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	The Angiotensin-(1-7) Mas receptor is the recently identified receptor of the biologically active heptapeptide Angiotensin-(1-7).1Angiotensin (Ang)-(1-7) is a metabolite of the well known peptide hormone Angiotensin (Ang) II, a key component of the renin-angiotensin system (RAS) that has a central role in cardiovascular homeostasis.Considerably interest in Ang-(1-7) and its receptor aroused in the last few years since it became apparent that it can counterbalance most of Ang II effects. Thus Ang-(1-7) has vasodilator and hypotensive effects as well as antiarrhythmic and cardioprotective roles.2, 3The Ang-(1-7) Mas receptor belongs to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and was originally described as a protooncogene.Signaling via the Ang-(1-7) Mas receptor is still poorly elucidated however, evidence indicates that the receptor is coupled to a Gq/11 protein that activates phospholipase C (PLC).2,3The Ang-(1-7) Mas receptor is expressed in several organs including heart, kidney, blood vessels, testis and brain. Studies with Ang-(1-7) Mas receptor knockout mice have demonstrated the key role of this receptor in cardiovascular regulation as well as in the regulation of learning and memory.2
Clonality	Polyclonal
Description	Anti-Angiotensin-(1-7) Mas Receptor Antibody (#AAR-013) is a highly specific antibody designed against an epitope of the rat protein. The antibody can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize Ang-(1-7) Mas receptor from rat, mouse, and human samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	3rd intracellular loop
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Proto-oncogene Mas, MAS1
UNSPSC Code	41116161
Note	Homology: Mouse, human - identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-AR013 Specifictiy: MAS1 Is Toxin: No KO-Validated: yes Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P12526
Gene Id	25153
Target	Proto-oncogene Mas, MAS1
Sequence	(C)KIRKNTWASHSSK, corresponding to amino acid residues 212-224 of the rat Angiotensin-(1-7) Mas receptor

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IC, IF, IHC, WB
Dilution	Immunohistochemistry paraffin embedded sections ihc: 1:100 Western blot wb: 1:200

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300022-1	AAR-013-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21300022-2	AAR-013_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300022-3	AAR-013_25 mcl	25 mcl	$597		Add to Cart
BHA21300022-4	AAR-013_50 mcl	50 mcl	$697		Add to Cart

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