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Home / Primary Antibodies / Polyclonal Antibodies

Anti-AMD1 Antibody Picoband®

SKU : BHA21001292

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Mfr.No.	A06146, A06146-10ug, A06146-Biotin, A06146-Cy3, A06146-Dylight488, A06146-Dylight550, A06146-Dylight594, A06146-FITC, A06146-HRP, A06146-APC, A06146-PE, A06146-iFluor647, A06146-carrier-free
Alternative Names	adenosylmethionine decarboxylase 1
Background	S-adenosylmethionine decarboxylase (AdoMet-DC), also known as S-adenosylmethionine decarboxylase proenzyme (SAMDC) or AMD1, is a key enzyme in polyamine biosynthesis. It is localized to chromosome region 6q21-q22. SAMDC has an unusual distribution in polysomes from cells of T lymphocyte origin. It associates predominantly with monosomes and small polysomes with none located in the preribosomal or ribonucleoprotein pool. SAMDC is a critical regulatory enzyme of the polyamine synthetic pathway, and a well-studied drug target. Since SAMDC is a key regulatory enzyme in the synthesis of spermidine and spermine, the marked increase in SAMDC activity in the neonate and the sustained high enzyme levels throughout adulthood, imply a role for these polyamines in both development and mature brain function.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-AMD1 Antibody Picoband® catalog # A06146. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human AMD1, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	38 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	S-adenosylmethionine decarboxylase proenzyme; AdoMetDC; SAMDC; 4.1.1.50
Tissue Specificity	Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	AMD1: P17707
Gene Id	262
Gene Name	AMD1
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br>

Reference	1. Ekstrom JL, Mathews II, Stanley BA, Pegg AE, Ealick SE The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold. Structure. 1999 May; 7(5):583-95. <br /><br />2. Hill JR, Morris DR. Cell-specific translation of S-adenosylmethionine decarboxylase mRNA. Regulation by the 5' transcript leader. J Biol Chem. 1992 Oct 25; 267(30):21886-93.<br /><br />3. Maric SC, Crozat A, Louhimo J, Knuutila S, Janne OA. The human S-adenosylmethionine decarboxylase gene: nucleotide sequence of a pseudogene and chromosomal localization of the active gene (AMD1) and the pseudogene (AMD2). Cytogenet Cell Genet. 1995; 70(3-4):195-9. <br /><br />4. Morrison LD, Becker L, Kish SJ. S-adenosylmethionine decarboxylase in human brain. Regional distribution and influence of aging. Brain Res Dev Brain Res. 1993 Jun 8; 73(2):237-41.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001292-1	A06146	100 ug	-	$370		Add to Cart
BHA21001292-2	A06146-10ug	10 ug	Sample	$99		Add to Cart
BHA21001292-3	A06146-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001292-4	A06146-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001292-5	A06146-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001292-6	A06146-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001292-7	A06146-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001292-8	A06146-FITC	100 ug	FITC	$570		Add to Cart
BHA21001292-9	A06146-HRP	100 ug	HRP	$570		Add to Cart
BHA21001292-10	A06146-APC	100 ug	APC	$670		Add to Cart
BHA21001292-11	A06146-PE	100 ug	PE	$670		Add to Cart
BHA21001292-12	A06146-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001292-13	A06146-carrier-free	100 ug	carrier-free	$370		Add to Cart

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