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Home / Primary Antibodies / Polyclonal Antibodies

Anti-AMACR Antibody Picoband®

SKU : BHA21000889

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Mfr.No.	PB9983, PB9983-10ug, PB9983-Biotin, PB9983-Cy3, PB9983-Dylight488, PB9983-Dylight550, PB9983-Dylight594, PB9983-FITC, PB9983-HRP, PB9983-APC, PB9983-PE, PB9983-iFluor647, PB9983-carrier-free
Alternative Names	Alpha-methylacyl-CoA racemase
Background	Alpha-methylacyl-CoA racemase (AMACR) is a mitochondrial and peroxisomal enzyme. It encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alteatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-AMACR Antibody Picoband® catalog # PB9983. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human AMACR, different from the related mouse and rat sequences by four amino acids.
Isotype	Rabbit IgG
Molecular Weight	42 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Alpha-methylacyl-CoA racemase;5.1.99.4;2-methylacyl-CoA racemase;AMACR;
Tissue Specificity	Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q9UHK6
Gene Id	23600
Gene Name	AMACR
Subcellular Location	Peroxisome . Mitochondrion .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry, 2-5ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. Amery, L., Fransen, M., De Nys, K., Mannaerts, G. P., Van Veldhoven, P. P. Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans. J. Lipid Res. 41: 1752-1759, 2000. 2. Clarke, C. E., Alger, S., Preece, M. A., Burdon, M. A., Chavda, S., Denis, S., Ferdinandusse, S., Wanders, R. J. A. Tremor and deep white matter changes in alpha-methylacyl-CoA racemase deficiency. Neurology 63: 188-189, 2004. 3. Dick, D., Horvath, R., Chinnery, P. F. AMACR mutations cause late-onset autosomal recessive cerebellar ataxia. Neurology 76: 1768-1770, 2011.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000889-1	PB9983	100 ug	-	$370		Add to Cart
BHA21000889-2	PB9983-10ug	10 ug	Sample	$99		Add to Cart
BHA21000889-3	PB9983-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000889-4	PB9983-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000889-5	PB9983-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000889-6	PB9983-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000889-7	PB9983-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000889-8	PB9983-FITC	100 ug	FITC	$570		Add to Cart
BHA21000889-9	PB9983-HRP	100 ug	HRP	$570		Add to Cart
BHA21000889-10	PB9983-APC	100 ug	APC	$670		Add to Cart
BHA21000889-11	PB9983-PE	100 ug	PE	$670		Add to Cart
BHA21000889-12	PB9983-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000889-13	PB9983-carrier-free	100 ug	carrier-free	$370		Add to Cart

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