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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Alpha Actinin 4/ACTN4 Antibody Picoband®

SKU : BHA21000880

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Mfr.No.	PB9974, PB9974-10ug, PB9974-Biotin, PB9974-Cy3, PB9974-Dylight488, PB9974-Dylight550, PB9974-Dylight594, PB9974-FITC, PB9974-HRP, PB9974-APC, PB9974-PE, PB9974-iFluor647, PB9974-carrier-free
Alternative Names	Alpha-actinin-4
Background	Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This ACTN4 gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Alpha Actinin 4/ACTN4 Antibody Picoband® catalog # PB9974. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is neces
Host	Rabbit
Immunogen Region	E.coli-derived human Alpha Actinin 4 recombinant protein (Position: E561-V661). Human Alpha Actinin 4 shares 99% and 98% amino acid (aa) sequence identity with mouse and rat Alpha Actinin 4, respectively.
Isotype	Rabbit IgG
Molecular Weight	105 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Alpha-actinin-4 ;Non-muscle alpha-actinin 4 ;ACTN4 ;
Tissue Specificity	Widely expressed. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	O43707
Gene Id	81
Gene Name	ACTN4
Subcellular Location	Nucleus . Cytoplasm . Cell junction . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC- 2, and bladder cancer KU-7). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human, Mouse, Rat

Reference	1. "Entrez Gene: ACTN4 actinin, alpha 4". 2. Kaplan, J. M., Kim, S. H., North, K. N., Rennke, H., Correia, L. A., Tong, H.-Q., Mathis, B. J., Rodriguez-Perez, J.-C., Allen, P. G., Beggs, A. H., Pollak, M. R. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis.Nature Genet. 24: 251-256, 2000.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000880-1	PB9974	100 ug	-	$370		Add to Cart
BHA21000880-2	PB9974-10ug	10 ug	Sample	$99		Add to Cart
BHA21000880-3	PB9974-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000880-4	PB9974-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000880-5	PB9974-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000880-6	PB9974-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000880-7	PB9974-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000880-8	PB9974-FITC	100 ug	FITC	$570		Add to Cart
BHA21000880-9	PB9974-HRP	100 ug	HRP	$570		Add to Cart
BHA21000880-10	PB9974-APC	100 ug	APC	$670		Add to Cart
BHA21000880-11	PB9974-PE	100 ug	PE	$670		Add to Cart
BHA21000880-12	PB9974-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000880-13	PB9974-carrier-free	100 ug	carrier-free	$370		Add to Cart

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