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Home / Primary Antibodies / Polyclonal Antibodies

Anti-alpha 2a Adrenergic Receptor/ADRA2A Antibody Picoband®

SKU : BHA21007388

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Mfr.No.	PA2197, PA2197-10ug, PA2197-Biotin, PA2197-Cy3, PA2197-Dylight488, PA2197-Dylight550, PA2197-Dylight594, PA2197-FITC, PA2197-HRP, PA2197-APC, PA2197-PE, PA2197-iFluor647, PA2197-carrier-free
Alternative Names	Alpha-2A adrenergic receptor
Background	The alpha-2A adrenergic receptor, also known as ADRA2A denotes the human gene encoding it. This gene is mapped to 10q25.2. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-alpha 2a Adrenergic Receptor/ADRA2A Antibody catalog # PA2197. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human alpha 2a Adrenergic Receptor, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Alpha-2A adrenergic receptor;Alpha-2 adrenergic receptor subtype C10;Alpha-2A adrenoreceptor;Alpha-2A adrenoceptor;Alpha-2AAR;ADRA2A;ADRA2R, ADRAR;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P08913
Gene Name	ADRA2A
Sequence	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
Subcellular Location	Cell membrane ; Multi-pass membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Philipp, M., Brede, M. E., Hadamek, K., Gessler, M., Lohse, M. J., Hein, L. Placental alpha-2-adrenoceptors control vascular development at the interface between mother and embryo. Nature Genet. 31: 311-315, 2002.<br /><br />2. Rosengren, A. H., Jokubka, R., Tojjar, D., Granhall, C., Hansson, O., Li, D.-Q., Nagaraj, V., Reinbothe, T. M., Tuncel, J., Eliasson, L., Groop, L., Rorsman, P., Salehi, A., Lyssenko, V., Luthman, H., Renstrom, E. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science 327: 217-220, 2010.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007388-1	PA2197	-	100 ug	$370		Add to Cart
BHA21007388-2	PA2197-10ug	Sample	10 ug	$99		Add to Cart
BHA21007388-3	PA2197-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007388-4	PA2197-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007388-5	PA2197-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007388-6	PA2197-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007388-7	PA2197-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007388-8	PA2197-FITC	FITC	100 ug	$570		Add to Cart
BHA21007388-9	PA2197-HRP	HRP	100 ug	$570		Add to Cart
BHA21007388-10	PA2197-APC	APC	100 ug	$670		Add to Cart
BHA21007388-11	PA2197-PE	PE	100 ug	$670		Add to Cart
BHA21007388-12	PA2197-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007388-13	PA2197-carrier-free	carrier-free	100 ug	$370		Add to Cart

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