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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Alkaline Phosphatase/ALPL Antibody Picoband®

SKU : BHA21006604

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Mfr.No.	PA1004-1, PA1004-1-10ug, PA1004-1-Biotin, PA1004-1-Cy3, PA1004-1-Dylight488, PA1004-1-Dylight550, PA1004-1-Dylight594, PA1004-1-FITC, PA1004-1-HRP, PA1004-1-APC, PA1004-1-PE, PA1004-1-iFluor647, PA1004-1-carrier-free
Alternative Names	Alkaline phosphatase, tissue-nonspecific isozyme
Background	Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. Liver/bone/kidney alkaline phosphatase, also known as tissue-nonspecific alkaline phosphatase, acts physiologically as a lipid-anchored phosphoethanolamine (PEA) and pyridoxal-5-prime-phosphate (PLP) ectophosphatase Mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked ly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Alkaline Phosphatase/ALPL Antibody catalog # PA1004-1. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	This isozyme may play a role in skeletal mineralization.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of rat Alkaline Phosphatase, different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	57 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Alkaline phosphatase, tissue-nonspecific isozyme;AP-TNAP;TNSALP;3.1.3.1;Alkaline phosphatase liver/bone/kidney isozyme;Alpl;
Tissue Specificity	Widely expressed, with highest expression in brain. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P08289
Gene Name	ALPL
Sequence	Contains 12 fibronectin type-I domains.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Rat, Mouse<br>

Reference	1. Weiss MJ, Hentho PS, Lafferty MA, Slaughter C, Raducha M, Harris H (Oct 1986). "Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase". Proc Natl Acad Sci U S A 83 (19): 71826.<br /><br />2. Swallow DM, Povey S, Parkar M, Andrews PW, Harris H, Pym B, Goodfellow P (May 1988). "Mapping of the gene coding for the human liver/bone/kidney isozyme of alkaline phosphatase to chromosome 1". Ann Hum Genet 50 (Pt 3): 22935.<br /><br />3. "Entrez Gene: ALPL alkaline phosphatase, liver/bone/kidney"<br /><br />4. Fedde, K. N., Whyte, M. P. Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5-prime-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study. Am. J. Hum. Genet. 47: 767-775, 1990.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006604-1	PA1004-1	-	100 ug	$370		Add to Cart
BHA21006604-2	PA1004-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21006604-3	PA1004-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006604-4	PA1004-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006604-5	PA1004-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006604-6	PA1004-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006604-7	PA1004-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006604-8	PA1004-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21006604-9	PA1004-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21006604-10	PA1004-1-APC	APC	100 ug	$670		Add to Cart
BHA21006604-11	PA1004-1-PE	PE	100 ug	$670		Add to Cart
BHA21006604-12	PA1004-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006604-13	PA1004-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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