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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Alkaline Phosphatase/ALPL Antibody Picoband®

SKU : BHA21006603

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Mfr.No.	PA1004, PA1004-10ug, PA1004-Biotin, PA1004-Cy3, PA1004-Dylight488, PA1004-Dylight550, PA1004-Dylight594, PA1004-FITC, PA1004-HRP, PA1004-APC, PA1004-PE, PA1004-iFluor647, PA1004-carrier-free
Alternative Names	Alkaline phosphatase, tissue-nonspecific isozyme
Background	Alkaline phosphatase (ALPL) removes phosphate groups from the 5' end of DNA and RNA, and from proteins, at high pH. Most mammals have 4 different isozymes: placental, placental like, intestinal and non tissue specific (found in liver, kidney and bone). Tissues with particularly high concentrations of ALP include the liver, bile ducts, placenta, and bone. ALPL is the alkaline phosphatase of skin fibroblasts ,the tissue-nonspecific type, and that it is active toward millimolar concentrations of the putative natural substrates phosphoethanolamine (PEA) and pyridoxal-5-prime-phosphate (PLP). ALPL gene exists in single copy in the haploid genome and is composed of 12 exons distributed over more than 50 kb.Damaged or diseased tissue releases enzymes into the blood, so serum ALP measurements can be abnormal in many conditions, including bone disease and liver disease.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Alkaline Phosphatase/ALPL Antibody catalog # PA1004. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	This isozyme may play a role in skeletal mineralization.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Alkaline Phosphatase, different from the related rat and mouse sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	80 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Alkaline phosphatase, tissue-nonspecific isozyme;AP-TNAP;TNSALP;3.1.3.1 ;Alkaline phosphatase liver/bone/kidney isozyme;ALPL;
Tissue Specificity	Widely expressed, with highest expression in brain. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P05186
Gene Name	ALPL
Sequence	Contains 12 fibronectin type-I domains.
Subcellular Location	Cell membrane ; Lipid-anchor, GPI-anchor .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat<br>

Reference	1. Fedde, K. N.; Whyte, M. P. : Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5-prime-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study. Am. J. Hum. Genet. 47: 767-775, 1990.<br /><br />2. Weiss, M. J.; Cole, D. E. C.; Ray, K.; Whyte, M. P.; Lafferty, M. A.; Mulivor, R. A.; Harris, H. : A missense mutation in the human liver/bone/kidney alkaline phosphatase gene causing a lethal form of hypophosphatasia. Proc. Nat. Acad. Sci. 85: 7666-7669, 1988.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006603-1	PA1004	-	100 ug	$370		Add to Cart
BHA21006603-2	PA1004-10ug	Sample	10 ug	$99		Add to Cart
BHA21006603-3	PA1004-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006603-4	PA1004-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006603-5	PA1004-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006603-6	PA1004-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006603-7	PA1004-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006603-8	PA1004-FITC	FITC	100 ug	$570		Add to Cart
BHA21006603-9	PA1004-HRP	HRP	100 ug	$570		Add to Cart
BHA21006603-10	PA1004-APC	APC	100 ug	$670		Add to Cart
BHA21006603-11	PA1004-PE	PE	100 ug	$670		Add to Cart
BHA21006603-12	PA1004-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006603-13	PA1004-carrier-free	carrier-free	100 ug	$370		Add to Cart

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