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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ALIX/PDCD6IP Antibody Picoband®

SKU : BHA21000672

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Mfr.No.	PB9770, PB9770-10ug, PB9770-Biotin, PB9770-Cy3, PB9770-Dylight488, PB9770-Dylight550, PB9770-Dylight594, PB9770-FITC, PB9770-HRP, PB9770-APC, PB9770-PE, PB9770-iFluor647, PB9770-carrier-free
Alternative Names	Programmed cell death 6-interacting protein
Background	Programmed cell death 6-interacting protein is a protein that in humans is encoded by the PDCD6IP gene. This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alteatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ALIX/PDCD6IP Antibody Picoband® catalog # PB9770. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Bi
Host	Rabbit
Immunogen Region	E.coli-derived human ALIX recombinant protein (Position: A2-D330). Human ALIX shares 96.7% and 95.2% amino acid (aa) sequence identity with mouse and rat ALIX, respectively.
Isotype	Rabbit IgG
Molecular Weight	96 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Programmed cell death 6-interacting protein;PDCD6-interacting protein;ALG-2-interacting protein 1;ALG-2-interacting protein X;Hp95;PDCD6IP;AIP1, ALIX, KIAA1375;
Tissue Specificity	Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q8WUM4
Gene Id	10015
Gene Name	PDCD6IP
Subcellular Location	Cytoplasm, cytosol . Melanosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Secreted, exosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human

Reference	1. "Entrez Gene: PDCD6IP programmed cell death 6 interacting protein". 2. Vito P, Pellegrini L, Guiet C, D'Adamio L (Feb 1999). "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction". J Biol Chem 274 (3): 153340.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000672-1	PB9770	100 ug	-	$370		Add to Cart
BHA21000672-2	PB9770-10ug	10 ug	Sample	$99		Add to Cart
BHA21000672-3	PB9770-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000672-4	PB9770-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000672-5	PB9770-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000672-6	PB9770-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000672-7	PB9770-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000672-8	PB9770-FITC	100 ug	FITC	$570		Add to Cart
BHA21000672-9	PB9770-HRP	100 ug	HRP	$570		Add to Cart
BHA21000672-10	PB9770-APC	100 ug	APC	$670		Add to Cart
BHA21000672-11	PB9770-PE	100 ug	PE	$670		Add to Cart
BHA21000672-12	PB9770-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000672-13	PB9770-carrier-free	100 ug	carrier-free	$370		Add to Cart

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