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Home / Primary Antibodies / Polyclonal Antibodies

Anti-AKT2 Antibody Picoband®

SKU : BHA21007503

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Mfr.No.	PB9043, PB9043-10ug, PB9043-Biotin, PB9043-Cy3, PB9043-Dylight488, PB9043-Dylight550, PB9043-Dylight594, PB9043-FITC, PB9043-HRP, PB9043-APC, PB9043-PE, PB9043-iFluor647, PB9043-carrier-free
Alternative Names	RAC-beta serine/threonine-protein kinase
Background	AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. This gene is mapped to 19q13.2. AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-AKT2 Antibody Picoband® catalog # PB9043. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human AKT2, different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	56 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	RAC-beta serine/threonine-protein kinase;2.7.11.1;Protein kinase Akt-2;Protein kinase B beta;PKB beta;RAC-PK-beta;AKT2;
Tissue Specificity	Expressed in all cell types so far analyzed.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P31751
Gene Id	208
Gene Name	AKT2
Sequence	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
Subcellular Location	Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI (3,4,5)P3 or PI (3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Mouse, Rat, - Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Cheng, J. Q., Ruggeri, B., Klein, W. M., Sonoda, G., Altomare, D. A., Watson, D. K., Testa, J. R. Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc. Nat. Acad. Sci. 93: 3636-3641, 1996. 2. Li, X., Monks, B., Ge, Q., Bibaum, M. J. Akt/PKB regulates hepatic metabolism by ly inhibiting PGC-1-alpha transcription coactivator. Nature 447: 1012-1016, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007503-1	PB9043	-	100 ug	$370		Add to Cart
BHA21007503-2	PB9043-10ug	Sample	10 ug	$99		Add to Cart
BHA21007503-3	PB9043-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007503-4	PB9043-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007503-5	PB9043-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007503-6	PB9043-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007503-7	PB9043-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007503-8	PB9043-FITC	FITC	100 ug	$570		Add to Cart
BHA21007503-9	PB9043-HRP	HRP	100 ug	$570		Add to Cart
BHA21007503-10	PB9043-APC	APC	100 ug	$670		Add to Cart
BHA21007503-11	PB9043-PE	PE	100 ug	$670		Add to Cart
BHA21007503-12	PB9043-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007503-13	PB9043-carrier-free	carrier-free	100 ug	$370		Add to Cart

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