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Home / Primary Antibodies / Polyclonal Antibodies

Anti-AIF/AIFM1 Antibody Picoband®

SKU : BHA21007413

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Mfr.No.	PA2232, PA2232-10ug, PA2232-Biotin, PA2232-Cy3, PA2232-Dylight488, PA2232-Dylight550, PA2232-Dylight594, PA2232-FITC, PA2232-HRP, PA2232-APC, PA2232-PE, PA2232-iFluor647, PA2232-carrier-free
Alternative Names	Apoptosis-inducing factor 1, mitochondrial
Background	Apoptosis-inducing factor 1, mitochondrial, also known as AIF or PDCD8 is a protein that in humans is encoded by the AIFM1 gene. AIFM1 gene is mapped to Xq26.1 based on an alignment of the AIFM1 sequence with the genomic sequence. This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. A related pseudogene has been identified on chromosome 10.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-AIF/AIFM1 Antibody catalog # PA2232. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human AIF, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Apoptosis-inducing factor 1, mitochondrial;1.1.1.-;Programmed cell death protein 8;AIFM1;AIF, PDCD8;
Tissue Specificity	Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O95831
Gene Name	AIFM1
Sequence	Belongs to the FAD-dependent oxidoreductase family.
Subcellular Location	Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, ICC, WB
Description	Immunocytochemistry , 0.5-1ug/ml, Human, Mouse, Rat<br>Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Rat, Human, Mouse<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Ghezzi, D., Sevrioukova, I., Inveizzi, F., Lamperti, C., Mora, M., D'Adamo, P., Novara, F., Zuffardi, O., Uziel, G., Zeviani, M. Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor. Am. J. Hum. Genet. 86: 639-649, 2010. <br /><br />2. Rinaldi, C., Grunseich, C., Sevrioukova, I. F., Schindler, A., Horkayne-Szakaly, I., Lamperti, C., Landoure, G., Kennerson, M. L., Buett, B. G., Bonnemann, C., Biesecker, L. G., Ghezzi, D., Zeviani, M., Fischbeck, K. H. Cowchock syndrome is associated with a mutation in apoptosis-inducing factor. Am. J. Hum. Genet. 91: 1095-1102, 2012.<br /><br />3. Yu, S.-W., Andrabi, S. A., Wang, H., Kim, N. S., Poirier, G. G., Dawson, T. M., Dawson, V. L. Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc. Nat. Acad. Sci. 103: 18314-18319, 2006.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007413-1	PA2232	-	100 ug	$370		Add to Cart
BHA21007413-2	PA2232-10ug	Sample	10 ug	$99		Add to Cart
BHA21007413-3	PA2232-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007413-4	PA2232-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007413-5	PA2232-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007413-6	PA2232-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007413-7	PA2232-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007413-8	PA2232-FITC	FITC	100 ug	$570		Add to Cart
BHA21007413-9	PA2232-HRP	HRP	100 ug	$570		Add to Cart
BHA21007413-10	PA2232-APC	APC	100 ug	$670		Add to Cart
BHA21007413-11	PA2232-PE	PE	100 ug	$670		Add to Cart
BHA21007413-12	PA2232-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007413-13	PA2232-carrier-free	carrier-free	100 ug	$370		Add to Cart

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